miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ

被引：19

作者：

Wang, Xuehui ^{[1
,2
]}

Yao, Zhilu ^{[1
,2
]}

Fang, Lin ^{[1
,2
]}

机构：

[1] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Thyroid & Breast Surg, Shanghai 200072, Peoples R China

[2] Nanjing Med Univ, Nanjing 211166, Peoples R China

来源：

PPAR RESEARCH | 2021年 / 2021卷

基金：

中国国家自然科学基金;

关键词：

INHIBITS PROLIFERATION; PGC-1-BETA; METASTASIS; APOPTOSIS;

D O I：

10.1155/2021/6661828

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In this study, we found that miR-22-3p expression was decreased in breast cancer (BC) cell lines and tissues. Overexpression of miR-22-3p inhibited the proliferation and migration of BC cells in vitro and in vivo, while depletion of miR-22-3p exhibited the opposite effect. Importantly, miR-22-3p could directly target PGC1 beta and finally regulate the PPAR gamma pathway in BC. In conclusion, miR-22-3p/PGC1 beta suppresses BC cell tumorigenesis via PPAR gamma, which may become a potential biomarker and therapeutic target.

引用

页数：15

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