Enantioselective Allylic Substitution of Morita-Baylis-Hillman Adducts Catalyzed by Chiral Bifunctional Ferrocenylphosphines

被引：22

作者：

Zhu, Linglong ^{[1
]}

Hu, Haiwen ^{[1
]}

Qi, Liang ^{[1
]}

Zheng, Yi ^{[1
]}

Zhong, Weihui ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Collaborat Innovat Ctr Green Pharmaceut Engn, Chao Wang Rd 18th, Hangzhou 310014, Zhejiang, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 2016卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Asymmetric catalysis; Amination; Phosphanes; Configuration determination; N-SULFONATED IMINES; INDOLE-DERIVATIVES; KINETIC RESOLUTION; ACTIVATED OLEFINS; HILIMAN REACTION; MBH-CARBONATES; ACETATES; ALKYLATION; AMINATION; ORGANOCATALYSTS;

D O I：

10.1002/ejoc.201600045

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of air-stable chiral ferrocenylphosphines (LB1-LB4) were prepared and used in the asymmetric allylic substitution of Morita-Baylis-Hillman (MBH) adducts with phthalimide under mild reaction conditions; the (R,S-Fc)-ferrocenylphosphine LB4 afforded the desired amination products 3 in moderate yields with excellent enantioselectivities. The absolute configuration of 3o was confirmed by X-ray analysis.

引用

页码：2139 / 2144

页数：6

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