Increased Expression of a Disintegrin and Metalloprotease-9 in Hepatocellular Carcinoma: Implications for Tumor Progression and Prognosis

被引：35
|
作者：
Tao, KaiShan [1 ]
Qian, NianSong [1 ]
Tang, Yu [2 ]
Ti, Zhenyu [1 ]
Song, WenJie [1 ]
Cao, DaYong [1 ]
Dou, KeFeng [1 ]
机构：
[1] Fourth Mil Med Univ, Xijing Hosp, Dept Hepatobiliary Surg, Xian 710032, Peoples R China
[2] Fourth Mil Med Univ, Xijing Hosp, Dept Ultrasound, Xian 710032, Peoples R China
来源：
JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 2010年 / 40卷 / 07期
基金：
中国国家自然科学基金;
关键词：
hepatocellular carcinoma; a disintegrin and metalloprotease; prognosis; DUCTAL ADENOCARCINOMA; PANCREATIC-CANCER; ADAM9; EXPRESSION; PROSTATE-CANCER; BREAST-CANCER; GROWTH-FACTOR; CELL LINES; PATHOGENESIS; RESECTION; GENES;
D O I：
10.1093/jjco/hyq030
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A disintegrin and metalloprotease-9 has been involved in the carcinogenesis of various solid tumors. However, its role in hepatocellular carcinoma remains unknown. The aim of this study was to investigate the clinicopathological and prognostic relevance of a disintegrin and metalloprotease-9 by immunohistochemistry. The expression profile of a disintegrin and metalloprotease-9 in association with the clinicopathological factors was determined by immunohistochemical analysis in hepatocellular carcinoma patients, and its potential prognostic value was investigated by comparing the survival rate between a disintegrin and metalloprotease-9-positive and a disintegrin and metalloprotease-9-negative patients. Hepatocellular carcinoma tissues with positive a disintegrin and metalloprotease-9 expression were larger and less differentiated than those with negative expression (P = 0.02 and 0.008, respectively). Portal venous invasion, hepatic venous invasion, bile duct invasion and intrahepatic metastasis were detected significantly more frequently in a disintegrin and metalloprotease-9-positive group (P = 0.009, 0.01, 0.03 and 0.02, respectively). In addition, high alpha-fetoprotein levels were significantly associated with the expression of a disintegrin and metalloprotease-9 in hepatocellular carcinoma (P = 0.01). Moreover, a disintegrin and metalloprotease-9-positive group had significantly poorer outcomes than a disintegrin and metalloprotease-9-negative group (P = 0.01) and was an independent prognostic factor for overall survival. A disintegrin and metalloprotease-9 is over-expressed in hepatocellular carcinoma tissues, consistent with findings in other tumor entities, and is an independent prognostic marker of overall survival following hepatectomy. Further studies are needed to investigate the precise function of a disintegrin and metalloprotease-9 in the progression of hepatocellular carcinoma.
引用
收藏
页码：645 / 651
页数：7
相关论文
共 50 条
  • [41] Over-expression of IMPDH2 is associated with tumor progression and poor prognosis in hepatocellular carcinoma
    He, Ying
    Zheng, Zhousan
    Xu, Yi
    Weng, Huiwen
    Gao, Ying
    Qin, Kai
    Rong, Jian
    Chen, Cui
    Yun, Miao
    Zhang, Jiaxing
    Ye, Sheng
    AMERICAN JOURNAL OF CANCER RESEARCH, 2018, 8 (08): : 1604 - 1614
  • [42] EPIGENETICS REGULATE GENE EXPRESSION OF METALLOPROTEASE-9 AND TISSUE INHIBITOR OF METALLOPROTEASE TYPE 2 IN ACUTE CORONARY SYNDROME
    Baudin, B.
    ATHEROSCLEROSIS, 2022, 355 : E26 - E26
  • [43] Increased expression of LncRNA GAPLINC is associated with tumor progression and predicts a poor prognosis in hepatocellular carcinoma patients (vol 10, pg 7921, 2017)
    Wang, Haikuan
    Shen, Shiqiang
    Zhang, Yong
    Gu, Xin
    Wang, Yongqiang
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2018, 11 (05): : 5394 - 5394
  • [44] Increased galectin-3 expression but not galectin-9 is related to poor prognosis in hepatocellular carcinoma
    Kong, Fei
    Jiang, Jing
    Jin, M. S.
    Ma, H. X.
    Niu, J. Q.
    Cao, Xueyuan
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2014, 29 : 193 - 193
  • [45] Structural Insights into the Catalytic Domains of Human Matrix Metalloprotease-2 and Human Matrix Metalloprotease-9: Implications for Substrate Specificities
    Irina Massova
    Rafael Fridman
    Shahriar Mobashery
    Molecular modeling annual, 1997, 3 : 17 - 30
  • [46] Regulation of insulin-like growth factor binding protein-5, four and a half lim-2, and a disintegrin and metalloprotease-9 expression in osteoblasts
    Govoni, KE
    Amaar, YG
    Kramer, A
    Winter, E
    Baylink, DJ
    Mohan, S
    GROWTH HORMONE & IGF RESEARCH, 2006, 16 (01) : 49 - 56
  • [47] Aberrant Expression of Disintegrin-Metalloprotease Proteins in the Formation and Progression of Uterine Cervical Cancer
    Shaker, Mohammed
    Yokoyama, Yuhki
    Mori, Seiji
    Tsujimoto, Masahiko
    Kawaguchi, Naomasa
    Kiyono, Tohru
    Nakano, Toru
    Matsuura, Nariaki
    PATHOBIOLOGY, 2011, 78 (03) : 149 - 161
  • [48] The correlation of NLRC3 expression with the progression and prognosis of hepatocellular carcinoma
    Ma, Ying-Yu
    Zhang, Guo-Hai
    Li, Jingjing
    Wang, Shi-Bing
    Hu, Zhi-Ming
    Zhang, Cheng-Wu
    Li, Erguang
    HUMAN PATHOLOGY, 2018, 82 : 273 - 281
  • [49] Decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma
    Wang, Jia-hong
    Wei, Wei
    Guo, Zhi-xing
    Shi, Ming
    Guo, Rong-ping
    JOURNAL OF TRANSLATIONAL MEDICINE, 2015, 13
  • [50] PHF21A expression as a biomarker of hepatocellular carcinoma progression and prognosis
    Huang, Jia-Qing
    Ji, Li-Chen
    Jing, Qiang-An
    He, Yi-Chen
    Ma, Ying-Yu
    Tong, Xiang-Min
    NEOPLASMA, 2022, 69 (06) : 1349 - +
12345