Toxic myopathies - Muscle biopsy features

被引:6
|
作者
Scola, Rosana Herminia [1 ]
Pereira, Eduardo Rafael [1 ]
Lorenzoni, Paulo Jose [1 ]
Werneck, Lineu Cesar [1 ]
机构
[1] Hosp Clin UFPR, Serv Doencas Neuromusculares, Dept Internal Med, Neuromuscular Neurol Div, BR-80060900 Curitiba, Parana, Brazil
关键词
myopathy; drug; iatrogenic myopathy; toxic myopathy; muscle biopsy;
D O I
10.1590/S0004-282X2007000100018
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Several drugs and toxic substances can cause muscular abnormalities and are frequent causes of acquired myopathies. We present a series of 32 patients, predominance of young adult patients, diagnosed with toxic myopathy. The most common substances inducing myopathy were corticosteroids (56.2%) followed by the propoxyphene, neuroleptics, zidovudine and drug-induced hypokalemia. The investigation showed normal serum creatine kinase levels in 65.4%, myopathic pattern of the needle electromyography in 40% and the more frequent histological diagnosis of the muscle biopsy was type 2 fiber atrophy (59.3%). Clinical features, etiology, course of the disease, serum levels of muscular enzymes, electromyographic features and, especially, muscle biopsy features are discussed.
引用
收藏
页码:82 / 86
页数:5
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