Tissue engineering of the urinary bladder

被引：0
|
作者：
Ram-Liebig, G [1 ]
Hakenberg, OW [1 ]
Wirth, MR [1 ]
机构：
[1] Tech Univ Dresden, Klin & Polklin Urol, D-01307 Dresden, Germany
来源：
UROLOGE A | 2004年 / 43卷 / 10期
关键词：
tissue engineering; urinary bladder; cell culture; urothelial cells; differentiation;
D O I：
10.1007/s00120-004-0690-7
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
In tissue engineering of the urinary bladder with autologous cell transplantation, high differentiation of the cells cultivated in vitro on biocompatible membranes is essential for the functionality of the tissue constructs after implantation. The terminal differentiation of superficial urothelial cells has a key role because of the barrier function of these cells against urine. The aim of this study was to determine optimized conditions for the creation of terminally differentiated urothelium to cover large membrane surfaces. This can bring us closer to the goal of using functioning tissue constructs in clinical trials.
引用
收藏
页码：1217 / +
页数：6
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