Bone marrow involvement in hematological malignancies and solid tumors

被引：0

作者：

Martin, S ^{[1
]}

Germing, U ^{[1
]}

Kronenwett, R ^{[1
]}

Haas, R ^{[1
]}

机构：

[1] Univ Dusseldorf, Klin Hamatol Onkol & Klin Immunol, D-40225 Dusseldorf, Germany

来源：

RADIOLOGE | 2000年 / 40卷 / 08期

关键词：

bone marrow; hematopoiesis; adhesion molecules; minimal residual disease;

D O I：

10.1007/s001170050795

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Bone marrow involvement is often observed in patients with hematological malignancies and solid tumors. Sensitive immunological and molecular biological methods allow the detection of isolated transformed cells in bone marrow samples. Like normal hematopoietic cells, tumor cells interact with bone marrow stroma through adhesion molecules. Since adhesion molecules play an essential role in the invasion and proliferation of malignant cells, new therapeutic approaches involving the inhibition of cell-cell and cell-matrix interactions are conceivable.

引用

页码：675 / 680

页数：8

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