Genome-wide screening for complete genetic loss in prostate cancer by comparative hybridization onto cDNA microarrays

被引：75
|
作者：
Clark, J
Edwards, S
Feber, A
Flohr, P
John, M
Giddings, I
Crossland, S
Stratton, MR
Wooster, R
Campbell, C
Cooper, CS [1 ]
机构：
[1] Inst Canc Res, Male Urol Canc Res Ctr, Mol Carcinogenesis Sect, Surrey, England
[2] Inst Canc Res, Male Urol Canc Res Ctr, Canc Res UK DNA Microarray Facil, Surrey, England
[3] Wellcome Trust Sanger Inst, Cambridge, England
[4] Univ Bristol, Adv Comp Res Ctr, Bristol BS8 1TH, Avon, England
来源：
ONCOGENE | 2003年 / 22卷 / 08期
关键词：
D O I：
10.1038/sj.onc.1206247
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We demonstrate that comparative genomic hybridization (CGH) onto cDNA microarrays may be used to carry out genome-wide screens for regions of genetic loss, including homozygous (complete) deletions that may represent the possible location of tumour suppressor genes in human cancer. Screening of the prostate cancer cell lines LNCaP, PC3 and DU145 allowed the mapping of specific regions where genome copy number appeared altered and led to the identification of two novel regions of complete loss at 17q21.31 (500 kb spanning STAT3) and at 10q23.1 (50-350 kb spanning SFTPA2) in the PC3 cell line.
引用
收藏
页码：1247 / 1252
页数：6
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