Morphology and proliferation of B16 melanoma cells in the presence of lanthanoid and Al3+ ions

被引：52
|
作者：
Sato, T [1 ]
Hashizume, M [1 ]
Hotta, Y [1 ]
Okahata, Y [1 ]
机构：
[1] Tokyo Inst Technol, Dept Biomol Engn, Midori Ku, Yokohama, Kanagawa 268501, Japan
来源：
BIOMETALS | 1998年 / 11卷 / 02期
关键词：
aluminium ion; B16 melanoma cell; lanthanoid; morphology; proliferation;
D O I：
10.1023/A:1009273827598
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effects of trivalent metal ions such as lanthanoid (La3+, Ce3+, Nd3+, Sm3+, Gd3+, Er3+, Yb3+, Lu3+) and Al3+ ions on the morphological change and proliferation of B16 melanoma cells in culture are discussed. These metal ions induced morphological transformations and decreased growth rates at doses of 1 mM. B16 melanoma cells treated with La3+, Ce3+, Nd3+, Sm3+, and Gd3+ showed polyhedrical spreading. Elongation of axones was dependent on the metal ions. B16 melanoma cells treated with Er3+, Yb3+, Lu3+, and Al3+ showed a long slender shape. Growth rates of melanoma cells in the presence of 1 mM of metal ions (La3+, Ce3+, Nd3+, Sm3+, Gd3+, Yb3+, Al3+) were significantly lower than that of control cells. Measurements of cell cycle indicated that the metal ions arrested the transitions from G(0)/G(1) to S state.
引用
收藏
页码：107 / 112
页数：6
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