Asymmetric addition reactions of Grignard reagents to chiral fluoral hemiacetal: Asymmetric synthesis of 1-substituted-2,2,2-trifluoroethylamines

被引：0
|
作者：
Ishii, A
Higashiyama, K
Mikami, K
机构：
[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 142, Japan
[2] Tokyo Inst Technol, Dept Chem Technol, Meguro Ku, Tokyo 152, Japan
来源：
SYNLETT | 1997年 / 12期
关键词：
1-substituted-2,2,2-trifluoroethylamines; asymmetric addition reaction; chiral fluoral hemiacetal; Grignard reagents; fluoral; (R)-phenylglycinol;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Asymmetric synthesis of 1-substituted-2,2,2-trifluoroethylamines is described starting from chiral fluoral hemiacetals derived from fluoral and (R)-phenylglycinol. The asymmetric addition reactions of Grignard reagents to the resultant imine are used in the key reaction step.
引用
收藏
页码：1381 / 1382
页数：2
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