Asymmetric addition reactions of Grignard reagents to chiral fluoral hemiacetal: Asymmetric synthesis of 1-substituted-2,2,2-trifluoroethylamines

被引：0

作者：

Ishii, A

Higashiyama, K

Mikami, K

机构：

[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 142, Japan

[2] Tokyo Inst Technol, Dept Chem Technol, Meguro Ku, Tokyo 152, Japan

来源：

SYNLETT | 1997年 / 12期

关键词：

1-substituted-2,2,2-trifluoroethylamines; asymmetric addition reaction; chiral fluoral hemiacetal; Grignard reagents; fluoral; (R)-phenylglycinol;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric synthesis of 1-substituted-2,2,2-trifluoroethylamines is described starting from chiral fluoral hemiacetals derived from fluoral and (R)-phenylglycinol. The asymmetric addition reactions of Grignard reagents to the resultant imine are used in the key reaction step.

引用

页码：1381 / 1382

页数：2

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