Novel dammarane-type glycosides from Gynostemma pentaphyllum

被引：49
|
作者：
Yin, F [1 ]
Hu, LH [1 ]
Pan, RX [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2004年 / 52卷 / 12期
关键词：
Gynostemma pentapkyllum; Cucurbitaceae; dammarane glycoside;
D O I：
10.1248/cpb.52.1440
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three new dammarane glycosides (1-3), together with five known compounds, gypenoside LXIX (4), gylongiposide I (5), gypenoside XLVIII (6), allantion (7) and vitexin (8) were isolated from the MeOH extract of the aerial parts of Gynostemma pentaphyllum. Compounds 5, 7, and 8 were isolated from this plant for the first time. Their structures were elucidated by 1D and 2D NMR spectra interpretation as well as by chemical degradation.
引用
收藏
页码：1440 / 1444
页数：5
相关论文
共 50 条
  • [41] New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum
    Phi Hung Nguyen
    Gauhar, Rehman
    Hwang, Seung Lark
    Trong Tuan Dao
    Park, Dong Chan
    Kim, Ji Eun
    Song, Hebok
    Huh, Tae Lin
    Oh, Won Keun
    BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (21) : 6254 - 6260
  • [42] Dammarane-type saponins from heat-processed Gynostemma pentaphyllum show fortified activity against A549 cells
    Xiang-Lan Piao
    Qian Wu
    Jing Yang
    Seo Young Park
    Dao-Jin Chen
    Hui-Min Liu
    Archives of Pharmacal Research, 2013, 36 : 874 - 879
  • [43] Nine new dammarane saponins from Gynostemma pentaphyllum
    Yin, Feng
    Zhang, Yi-Nan
    Yang, Zheng-Yi
    Hu, Li-Hong
    CHEMISTRY & BIODIVERSITY, 2006, 3 (07) : 771 - 782
  • [44] Dammarane-type saponins from heat-processed Gynostemma pentaphyllum show fortified activity against A549 cells
    Piao, Xiang-Lan
    Wu, Qian
    Yang, Jing
    Park, Seo Young
    Chen, Dao-Jin
    Liu, Hui-Min
    ARCHIVES OF PHARMACAL RESEARCH, 2013, 36 (07) : 874 - 879
  • [45] Profiling and activity screening of Dammarane-type triterpen saponins from Gynostemma pentaphyllum with glucose-dependent insulin secretory activity
    Lundqvist, Lena C. E.
    Rattigan, Darren
    Ehtesham, Emad
    Demmou, Camila
    Ostenson, Claes-Goran
    Sandstrom, Corine
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [46] Profiling and activity screening of Dammarane-type triterpen saponins from Gynostemma pentaphyllum with glucose-dependent insulin secretory activity
    Lena C. E. Lundqvist
    Darren Rattigan
    Emad Ehtesham
    Camila Demmou
    Claes-Göran Östenson
    Corine Sandström
    Scientific Reports, 9
  • [47] Cytotoxic dammarane triterpenoids from the hydrolyzate of Gynostemma pentaphyllum
    Wang, Jun
    Wang, Cheng-Bo
    Meng, Xian-Hua
    Wang, Wei-Feng
    Chai, Tian
    Farimani, Mahdi Moridi
    Yang, Jun-Li
    PHYTOCHEMISTRY LETTERS, 2021, 46 : 136 - 142
  • [48] Dammarane-type saponins from Gynostemma pentaphyllum and their anti-aging activities via up-regulating mitochondria related proteins
    Liang, Hai-Zhen
    Lu, Peng-Xin
    Chu, Li-Li
    Li, Gang
    Li, Chuan-Biao
    Chen, Xiao-Juan
    Zhang, Jie
    Song, Juan
    Zhang, Tao
    Luo, Ying
    Hu, Ying
    Ma, Bai-Ping
    PHYTOCHEMISTRY, 2023, 213
  • [49] Two new dammarane-type glycosides from Phlomis umbrosa
    Ding, Ming-Ming
    Yan, Fu-Lin
    Tan, Jing
    Bai, Yi-Xiao
    Wang, Xiang
    Yang, Yan-Xia
    NATURAL PRODUCT RESEARCH, 2014, 28 (01) : 18 - 23
  • [50] Protein tyrosine phosphatase 1B inhibitory effect by dammarane-type triterpenes from hydrolyzate of total Gynostemma pentaphyllum saponins
    Zhang, Xiao-Shu
    Bi, Xiu-Li
    Wan-Xiao
    Cao, Jia-Qing
    Xia, Xi-Chun
    Diao, Yun-Peng
    Zhao, Yu-Qing
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (01) : 297 - 300
12345