Prime time for the recycling endosome

被引：1
|
作者：
Ceresa, Brian P. [1 ]
机构：
[1] Univ Louisville, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA
来源：
EMBO JOURNAL | 2021年 / 40卷 / 14期
关键词：
D O I：
10.15252/embj.2021108758
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Receptor crosstalk is the phenomenon by which one cell surface receptor communicates with another to modulate its activity. In this issue, Smith et al (2021) demonstrate that such crosstalk may involve endocytic trafficking, as ligands promoting FGFR2b recycling induce a specific "priming" EGFR phosphorylation to direct unliganded EGFR to the recycling endosome, slow the lysosomal degradation of ligand-stimulated EGFR, and enhance signaling and cell proliferation.
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页数：3
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