Synthesis, antifungal and antimicrobial activity of alkylphospholipids

被引：34
|
作者：
Obando, Daniel
Widmer, Fred
Wright, Lesley C.
Sorrell, Tania C.
Jolliffe, Katrina A. [1 ]
机构：
[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia
[2] Univ Sydney, Ctr Infect Dis & Microbiol, Westmead Millenium Inst, Westmead, NSW 2145, Australia
[3] Univ Sydney, Ctr Clin Res Excellence Infect Bioeth & Haematol, Westmead, NSW 2145, Australia
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 15期
基金：
英国医学研究理事会; 澳大利亚研究理事会;
关键词：
alkylphospholipids; hexadecylphosphocholine; antifungal activity; antibacterial activity; haemolytic activity;
D O I：
10.1016/j.bmc.2007.05.028
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The antifungal, antibacterial and haemolytic activity of a series of alkylphosphocholines (e.g., miltefosine) and alkylglycerophosphocholines (e.g., edelfosine) has been investigated. These compound classes exhibit significant antifungal and moderate antibacterial activities. Several new alkylphosphocholine derivatives with amide or ester bonds in the alkyl chain have been synthesised. These compounds show much lower haemolytic activity than miltefosine. Alkylphosphocholines and alkylglycerophosphocholines show significant promise as novel orally available antifungal and antibacterial therapeutics. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5158 / 5165
页数：8
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