Mature T cells alone separate GVL from GVHD: The need for better controls

被引:1
|
作者
Chen, BJ [1 ]
Son, J [1 ]
Cui, X [1 ]
Chao, NJ [1 ]
机构
[1] Duke Univ, Med Ctr, Durham, NC USA
关键词
D O I
10.1016/j.bbmt.2004.12.143
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
142
引用
收藏
页码:48 / 49
页数:2
相关论文
共 50 条
  • [31] Retention of Donor T Cells in Lymphohematopoietic Tissue and Augmentation of Tissue PD-L1 Protection for Prevention of GVHD While Preserving GVL Activity
    Song, Qingxiao
    Nasri, Ubaydah
    Nakamura, Ryotaro
    Martin, Paul J.
    Zeng, Defu
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [32] Donor CD8+ T-Cells mediate GVL without GVHD in recipients conditioned with anti-CD3 mAB.
    Zhang, Chunyan
    Lou, Jingwei
    Todorov, Ivan
    Li, Nainong
    Lin, Chia-Lei
    Cao, Yuan
    Contag, Christopher
    Kandeel, Fouard
    Forman, Stephen
    Zeng, Defu
    CLINICAL IMMUNOLOGY, 2006, 119 : S36 - S36
  • [33] Abrogation of Donor T Cell IL-21 Signaling Leads to Tissue-Specific Modulation of Immunity and Separation of Gvhd From GVL
    Hanash, Alan M.
    Kappel, Lucy W.
    Yim, Nury L.
    Nejat, Rebecca A.
    Goldberg, Gabrielle L.
    Smith, Odette M.
    Rao, Uttam K.
    Dykstra, Lindsay
    Na, Il-Kang
    Holland, Amanda M.
    Liu, Chen
    Murphy, George F.
    Leonard, Warren J.
    Heller, Glenn
    van den Brink, Marcel R. M.
    BLOOD, 2010, 116 (21) : 321 - 322
  • [34] Host Tissue PD-L1 Separates GVL Effect from Gvhd after Temporary Depletion of Donor CD4+ T Cells Early after HCT
    Ni, Xiong
    Song, Qingxiao
    Deng, Ruishu
    Jin, Hua
    Cassady, Kaniel M.
    Zhang, Mingfeng
    Forman, Stephen J.
    Martin, Paul J.
    Wang, Jianmin
    Zeng, Defu
    BLOOD, 2015, 126 (23)
  • [35] ABROGATION OF DONOR T CELL IL-21 SIGNALING LEADS TO TISSUE-SPECIFIC MODULATION OF IMMUNITY AND SEPARATION OF GVHD FROM GVL
    Hanash, A. M.
    Kappel, L. W.
    Yim, N. L.
    Nejat, R. A.
    Goldberg, G. L.
    Smith, O. M.
    Rao, U. K.
    Dykstra, L.
    Na, I-K
    Holland, A. M.
    Liu, C.
    Murphy, G. F.
    Leonard, W. J.
    Heller, G.
    van den Brink, M. R. M.
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2011, 17 (02) : S163 - S163
  • [36] Tregs combined with mature donor T cells hasten immune reconstitution without triggering GvHD in HLA haploidentical transplantation
    Mauro Di Ianni
    Franca Falzetti
    Massimo F Martelli
    Arthritis Research & Therapy, 13 (Suppl 2):
  • [37] Tregs combined with mature donor T cells hasten immune reconstitution without triggering GvHD in HLA haploidentical transplantation
    Di Ianni, Mauro
    Falzetti, Franca
    Martelli, Massimo F.
    ARTHRITIS RESEARCH & THERAPY, 2011, 13
  • [38] Donor T Cells Intrinsic Responses to Damps Regulated By Siglec-G-CD24 Axis Mitigate Gvhd but Maintain GVL in Experimental BMT Model
    Toubai, Tomomi
    Rossi, Corinne
    Oravecz-Wilson, Katherine
    Mathewson, Nathan
    Zajac, Cynthia
    Liu, Chen
    Brabbs, Stuart
    Redman, Bailey
    Tamaki, Hiroya
    Wu, Julia
    Sun, Yaping
    Zheng, Pang
    Liu, Yang
    Reddy, Pavan
    BLOOD, 2015, 126 (23)
  • [39] Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL
    Hanash, Alan M.
    Kappel, Lucy W.
    Yim, Nury L.
    Nejat, Rebecca A.
    Goldberg, Gabrielle L.
    Smith, Odette M.
    Rao, Uttam K.
    Dykstra, Lindsay
    Na, Il-Kang
    Holland, Amanda M.
    Dudakov, Jarrod A.
    Liu, Chen
    Murphy, George F.
    Leonard, Warren J.
    Heller, Glenn
    van den Brink, Marcel R. M.
    BLOOD, 2011, 118 (02) : 446 - 455
  • [40] Delayed GCV-mediated ablation of ΔCD34-TK transduced and selected murine T cells preserves GVL activity while mitigating GVHD
    Rettig, MP
    Ritchey, JK
    Prior, JL
    Piwnica-Worms, D
    Bonybadi, ML
    DiPersio, JF
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2006, 12 (02) : 65 - 66