Synthesis of 2-alkyl triazoles with solvothermal conditions

被引：2
|
作者：
Ma, Youcai [1 ]
Zhang, Xiaohui [1 ]
Yang, Yawen [1 ]
Hu, Liangzhen [1 ]
Xiong, Yan [1 ,2 ,3 ,4 ]
机构：
[1] Chongqing Univ, Sch Chem & Chem Engn, Chongqing Key Lab Theoret & Computat Chem, Chongqing 401331, Peoples R China
[2] Nankai Univ, State Key Lab Elemento Organ Chem, Tianjin 300071, Peoples R China
[3] Xinjiang Inst Engn, Collaborat Innovat Ctr High Value Transformat Coal, Sch Chem & Environm Engn, Urumqi 830091, Xinjiang, Peoples R China
[4] Chongqing Univ, Sch Chem & Chem Engn, Chongqing Key Lab Theoret & Computat Chem, Chongqing 401331, Peoples R China
来源：
TETRAHEDRON | 2022年 / 113卷
关键词：
2-Alkyl triazoles; Metal-free; Nucleophilic substitution; Potassium carbonate; 3-Triazoles; N-ALKYLATION; BENZOTRIAZOLE; 1,2,3-TRIAZOLES; EFFICIENT; AMINATION; ANALOGS; AZIDES;
D O I：
10.1016/j.tet.2022.132765
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general protocol for the straightforward access to 2-alkyl triazoles with alkyl halides as the readily available alkylation reagents, by using a well-organized nucleophilic substitution strategy under metal free and solvothermal conditions has been developed. Various alkyl substitutions on 2-site of triazoles occurred and were mainly examined in the text. Particularly, the reactions between linear bisbromo alkanes and 1,2,3-triazoles were executed to yield bromoalkyl triazoles and bistriazoles, and realkylations of bromoalkyl triazoles were achieved through addition of triazoles. This procedure is convenient and generally affords the 2-alkylated products, which are slightly scarce under present synthetic methodologies. (c) 2022 Elsevier Ltd. All rights reserved.
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页数：8
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