Energy sensor as a new regulator of FGF23 synthesis

被引：4
|
作者：
Komaba, Hirotaka [1 ,2 ,3 ]
机构：
[1] Tokai Univ, Sch Med, Div Nephrol Endocrinol & Metab, 143 Shimo Kasuya, Isehara, Kanagawa 2591193, Japan
[2] Tokai Univ, Sch Med, Interact Translat Res Ctr Kidney Dis, Isehara, Kanagawa, Japan
[3] Tokai Univ, Inst Med Sci, Isehara, Kanagawa, Japan
来源：
KIDNEY INTERNATIONAL | 2018年 / 94卷 / 03期
关键词：
LEFT-VENTRICULAR HYPERTROPHY; ACTIVATED PROTEIN-KINASE;
D O I：
10.1016/j.kint.2018.05.008
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Phosphate plays an important role in biological energy cycle, but the interaction of cellular energy metabolism with fibroblast growth factor 23 production has been less well characterized. Glosse and colleagues now demonstrate that AMP-activated protein kinase, a cellular energy sensor, regulates fibroblast growth factor 23 production. Interestingly, AMP-activated protein kinase-deficient mice show high fibroblast growth factor 23 levels, normal phosphate levels, and cardiac hypertrophy, which resemble those seen in patients with moderate chronic kidney disease. Copyright (C) 2018, International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：453 / 455
页数：3
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