Evaluation of [C-11]RTI-121 as a selective radioligand for PET studies of the dopamine transporter

被引：16

作者：

Hume, SP

Luthra, SK

Brown, DJ

OpackaJuffry, J

Osman, S

Ashworth, S

Myers, R

Brady, F

Carroll, FI

Kuhar, MJ

Brooks, DJ

机构：

[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,MRC CLIN SCI CTR,CYCLOTRON UNIT,NEUROSCI GRP,LONDON W12 0NN,ENGLAND

[2] RES TRIANGLE INST,DEPT ORGAN & MED CHEM,RES TRIANGLE PK,NC 27709

[3] NIDA,NEUROSCI BRANCH,ADDICT RES CTR,BALTIMORE,MD 21224

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1996年 / 23卷 / 03期

关键词：

dopamine transporter; RTI-121; positron emission tomography;

D O I：

10.1016/0969-8051(96)00019-4

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The cocaine analogue RTI-121 (3 beta-(4-iodophenyl)tropane-2 beta-carboxylic acid isopropyl ester), when labeled with carbon-11, was evaluated in rats as a potential PET ligand for the dopamine transporter. The compound gave in vivo striatum:cerebellum ratios that were similar to those obtained with the related ligand [C-11]RTI-55 (2 beta-(4-iodophenyl)tropane-2 beta-carboxylic acid methyl ester) but showed a much greater selectivity for the dopamine compared with the 5-HT uptake site, The results indicate that [C-11]RTI-121 could be used in preference to [C-11]RTI-55 in man. Experimentally, [C-11]RTI-121 has potential in the quantification of dopamine terminal function in rat models of disease, using a combination of autoradiography, postmortem sampling, and in vivo tomography.

引用

页码：377 / 384

页数：8

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