Induction of donor-specific tolerance in living donor kidney transplant recipients through clinical MIC cell infusion - a phase I study (TOL-1)

被引:0
|
作者
Morath, Christian [1 ]
Schmitt, Anita [2 ]
Kleist, Christian [3 ]
Daniel, Volker [4 ]
Opelz, Gerhard [4 ]
Suesal, Caner [4 ]
Kaelble, Florian [1 ]
Sommerer, Claudia [1 ]
Wang, Lei [2 ]
Hueckelhoven, Angela [2 ]
Mehrabi, Arianeb [5 ]
Merle, Uta [6 ]
da Silva, Luiza Pego [1 ]
Mueller-Tidow, Carsten [2 ]
Zeier, Martin [1 ]
Schaier, Matthias [1 ]
Schmitt, Michael [2 ]
Terness, Peter [4 ]
机构
[1] Univ Clin Heidelberg, Div Nephrol, Heidelberg, Germany
[2] Univ Clin Heidelberg, Dept Internal Med 5, Heidelberg, Germany
[3] Univ Clin Heidelberg, Dept Nucl Med, Heidelberg, Germany
[4] Heidelberg Univ, Inst Immunol, Heidelberg, Germany
[5] Univ Clin Heidelberg, Allgemein Viszeral & Transplantat Chirurg, Heidelberg, Germany
[6] Univ Clin Heidelberg, Dept Internal Med 4, Heidelberg, Germany
关键词
D O I
暂无
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
P111
引用
收藏
页码:229 / 230
页数:2
相关论文
共 50 条
  • [31] Single Fixed Low Dose of Rituximab as Induction Therapy for Kidney Transplant Recipients Highly Sensitized with Donor-Specific Antibodies
    Tomita, Y.
    Iwadoh, K.
    Nakajima, I.
    Fuchinoue, S.
    Koyama, I.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2013, 13 : 281 - 281
  • [32] Induction of donor-specific tolerance by chimeric class I MHC molecules bearing donor alpha(1) helical amino acids
    Wang, M
    Yu, J
    Wang, ME
    Tian, L
    Stepkowski, SM
    Kahan, BD
    TRANSPLANTATION PROCEEDINGS, 1997, 29 (1-2) : 1224 - 1225
  • [33] Continuing observations on the regulatory effects of donor-specific bone marrow cell infusions and chimerism in kidney transplant recipients
    Garcia-Morales, R
    Carreno, M
    Mathew, J
    Cirocco, R
    Zucker, K
    Ciancio, G
    Burke, G
    Roth, D
    Temple, D
    Fuller, L
    Esquenazi, V
    Eskind, L
    Kenyon, NS
    Ricordi, C
    Tzakis, A
    Miller, J
    TRANSPLANTATION, 1998, 65 (07) : 956 - 965
  • [34] Clinical Significance of Pretransplant Donor-Specific Antibodies in the Setting of Negative Cell-Based Flow Cytometry Crossmatching in Kidney Transplant Recipients
    Adebiyi, O. O.
    Gralla, J.
    Klem, P.
    Freed, B.
    Davis, S.
    Wiseman, A. C.
    Cooper, J. E.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2016, 16 (12) : 3458 - 3467
  • [35] Long Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Kidney Transplant Recipients.
    Leventhal, J.
    Galvin, J.
    Mathew, J.
    Gallon, L.
    Belshe, D.
    Gibson, M.
    Ravindra, K.
    Horwitz, M.
    Ildstad, S.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2022, 22 : 510 - 511
  • [36] Interim Results of a Phase 1 Trial of Treg Adoptive Cell Transfer (TRACT) in Living Donor Kidney Transplant Recipients
    Leventhal, J.
    LeFever, A.
    Skaro, A.
    Gallon, L.
    Mathew, J.
    Stare, D.
    Konieczna, I.
    He, J.
    Johnson, G.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2015, 15
  • [37] The detrimental effect of donor-specific antibodies is irrespective of its level in highly-immunized living donor kidney transplant recipients: A case-control series
    Tramper, T.
    Roelen, D. L.
    Brand-Schaaf, S. H.
    Kal-van Gestel, J. A.
    Kho, M. M. L.
    Reinders, M. E. J.
    Roodnat, J. I.
    van de Wetering, J.
    Betjes, M. G. H.
    de Weerd, A. E.
    FRONTIERS IN IMMUNOLOGY, 2023, 13
  • [38] Tolerance induction in HLA disparate living donor kidney transplantation by facilitating cell-enriched donor stem cell Infusion: The importance of durable chimerism
    Leventhal, Joseph R.
    Ildstad, Suzanne T.
    HUMAN IMMUNOLOGY, 2018, 79 (05) : 272 - 276
  • [39] Impact of Rituximab Induction Therapy on Donor-specific Anti-HLA Antibodies in Abo-compatible Kidney Transplant Recipients
    Yagisawa, T.
    Kanzawa, T.
    Unagami, K.
    Furusawa, M.
    Inui, M.
    Ishida, H.
    Tanabe, K.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2021, 21 : 702 - 702
  • [40] Analysis of T-cell alloantigen response via a direct pathway in kidney transplant recipients with donor-specific antibodies
    Iwahara, Naoya
    Hotta, Kiyohiko
    Iwami, Daiki
    Tanabe, Tatsu
    Hirose, Takayuki
    Shinohara, Nobuo
    TRANSPLANTATION, 2024, 108 (9S)