Changes in nitrite and nitrate (NO2-/NO3-) levels in cerebrospinal fluid of patients with multiple sclerosis

被引：51
|
作者：
Yamashita, T
Ando, Y
Obayashi, K
Uchino, M
Ando, M
机构：
[1] Kumamoto Univ, Sch Med, Dept Internal Med 1, Kumamoto 860, Japan
[2] Kumamoto Univ, Sch Med, Dept Neurol, Kumamoto 860, Japan
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 1997年 / 153卷 / 01期
关键词：
multiple sclerosis; nitric oxide synthase; NO2-/NO3-; cerebrospinal fluid; methylpredonisolone; activity;
D O I：
10.1016/S0022-510X(97)00183-4
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
To compare the change in nitric oxide (NO) metabolism in patients with multiple sclerosis (MS) in different clinical stages, such as exacerbation, remission, and 1-2 months after methylpredonisolone administration, we measured the nitrite and nitrate (NO2-/NO3-) levels in the cerebrospinal fluid (CSF). In the extreme stage of MS exacerbation, those levels were remarkably elevated, compared with those both after methylpredonisolone administration and remission. These results suggest that, in addition to MRI study, measurement of NO metabolites in the CSF may give information to help us understand the activity of MS and effect of drugs on the disease. (C) 1997 Elsevier Science B.V.
引用
收藏
页码：32 / 34
页数：3
相关论文
共 50 条
  • [41] INTERLEUKIN-2 LEVELS IN SERUM AND CEREBROSPINAL-FLUID OF MULTIPLE-SCLEROSIS PATIENTS
    GALLO, P
    PICCINNO, M
    PAGNI, S
    TAVOLATO, B
    ANNALS OF NEUROLOGY, 1988, 24 (06) : 795 - 797
  • [42] Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis
    Di Filippo, M.
    Pini, L. A.
    Pelliccioli, G. P.
    Calabresi, P.
    Sarchielli, P.
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2008, 79 (11): : 1224 - 1229
  • [43] ELEVATED VITAMIN LEVELS IN CEREBROSPINAL FLUID IN MULTIPLE SCLEROSIS
    SOBOTKA, H
    CHRISTOFF, N
    BAKER, H
    PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1958, 98 (03): : 534 - 536
  • [44] Elevated levels of antibodies to sulfatide in cerebrospinal fluid from patients with multiple sclerosis
    Ilyas, AA
    Chen, ZW
    Cook, SD
    JOURNAL OF NEUROCHEMISTRY, 1997, 69 : S155 - S155
  • [45] Elevated levels of PPAR-gamma in the cerebrospinal fluid of patients with multiple sclerosis
    Szalardy, Levente
    Zadori, Denes
    Tanczos, Ervin
    Simu, Mihaela
    Bencsik, Krisztina
    Vecsei, Laszlo
    Klivenyi, Peter
    NEUROSCIENCE LETTERS, 2013, 554 : 131 - 134
  • [46] Cerebrospinal fluid (CSF) transferrin levels are reduced in patients with early multiple sclerosis
    Khalil, M.
    Riedlbauer, B.
    Langkammer, C.
    Enzinger, C.
    Ropele, S.
    Stojakovic, T.
    Scharnagl, H.
    Culea, V.
    Petzold, A.
    Archelos, J. J.
    Fuchs, S.
    Fazekas, F.
    JOURNAL OF NEUROLOGY, 2013, 260 : S39 - S40
  • [47] Cerebrospinal Fluid IgM Levels in Association With Inflammatory Pathways in Multiple Sclerosis Patients
    Magliozzi, Roberta
    Mazziotti, Valentina
    Montibeller, Luigi
    Pisani, Anna, I
    Marastoni, Damiano
    Tamanti, Agnese
    Rossi, Stefania
    Crescenzo, Francesco
    Calabrese, Massimiliano
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2020, 14
  • [48] CYTOKINE LEVELS IN THE CEREBROSPINAL-FLUID AND SERUM OF PATIENTS WITH MULTIPLE-SCLEROSIS
    MAIMONE, D
    GREGORY, S
    ARNASON, BGW
    REDER, AT
    JOURNAL OF NEUROIMMUNOLOGY, 1991, 32 (01) : 67 - 74
  • [49] Amyloid-β peptide levels in serum and cerebrospinal fluid of multiple sclerosis patients
    Coyle, PK
    Mehta, PD
    ANNALS OF NEUROLOGY, 1999, 46 (03) : 489 - 489
  • [50] Neuroactive steroid levels in plasma and cerebrospinal fluid of male multiple sclerosis patients
    Caruso, Donatella
    Melis, Marta
    Fenu, Giuseppe
    Giatti, Silvia
    Romano, Simone
    Grimoldi, Maria
    Crippa, Donatella
    Marrosu, Maria Giovanna
    Cavaletti, Guido
    Melcangi, Roberto Cosimo
    JOURNAL OF NEUROCHEMISTRY, 2014, 130 (04) : 591 - 597
12345