Changes in nitrite and nitrate (NO2-/NO3-) levels in cerebrospinal fluid of patients with multiple sclerosis

被引：51
|
作者：
Yamashita, T
Ando, Y
Obayashi, K
Uchino, M
Ando, M
机构：
[1] Kumamoto Univ, Sch Med, Dept Internal Med 1, Kumamoto 860, Japan
[2] Kumamoto Univ, Sch Med, Dept Neurol, Kumamoto 860, Japan
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 1997年 / 153卷 / 01期
关键词：
multiple sclerosis; nitric oxide synthase; NO2-/NO3-; cerebrospinal fluid; methylpredonisolone; activity;
D O I：
10.1016/S0022-510X(97)00183-4
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
To compare the change in nitric oxide (NO) metabolism in patients with multiple sclerosis (MS) in different clinical stages, such as exacerbation, remission, and 1-2 months after methylpredonisolone administration, we measured the nitrite and nitrate (NO2-/NO3-) levels in the cerebrospinal fluid (CSF). In the extreme stage of MS exacerbation, those levels were remarkably elevated, compared with those both after methylpredonisolone administration and remission. These results suggest that, in addition to MRI study, measurement of NO metabolites in the CSF may give information to help us understand the activity of MS and effect of drugs on the disease. (C) 1997 Elsevier Science B.V.
引用
收藏
页码：32 / 34
页数：3
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