Spectrophotometric determination of hydroxylamine and its derivatives in pharmaceuticals

被引:18
|
作者
Deepa, B
Balasubramanian, N
Nagaraja, KS [1 ]
机构
[1] Loyola Coll, Dept Chem, LIFE, Madras 600034, Tamil Nadu, India
[2] Indian Inst Technol, Dept Chem, Madras 600036, Tamil Nadu, India
关键词
hydroxylamine; spectrophotometry; diazo coupling; N-(1-naphthyl)ethylenediamine dihydrochloride;
D O I
10.1248/cpb.52.1473
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A sensitive spectrophotometric method for the determination of hydroxylamine is described. The method is based on the oxidation of hydroxylamine to nitrite using sodium arsenate under alkaline condition. The formed nitrite is determined based on the diazo coupling reaction between p-nitroaniline and N-(1-naphthyl)ethylenediamine dihydrochloride [NEDA]. The system obeys Beer's law over the concentration range 0-7 mug of hydroxylamine at 545 nm and the colour is stable for 3 h. The molar absorptivity of the colour system is found to be 6.7 X 10(4) l mol(-1) cm(-1). The relative standard deviation is 1.2% for ten determinations at 4 mug of hydroxylamine. Interferences due to various foreign ions have been studied and the method has been applied to the determination of hydroxylamine and its derivatives used in pharmaceutical formulations after hydrolysis.
引用
收藏
页码:1473 / 1475
页数:3
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