Cyclometalated gold(III) complexes with N-heterocyclic carbene ligands as topoisomerase I poisons

被引：143
|
作者：
Yan, Jessie Jing
Chow, Andy Lok-Fung
Leung, Chung-Hang
Sun, Raymond Wai-Yin
Ma, Dik-Lung
Che, Chi-Ming [1 ]
机构：
[1] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 22期
关键词：
METAL-COMPLEXES; DNA-BINDING; ANTICANCER; CYTOTOXICITY; CHEMISTRY; DRUGS;
D O I：
10.1039/c001216e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A panel of stable [Au(R-C boolean AND N boolean AND C)(N-heterocyclic carbene)](+) complexes displays prominent in vitro anticancer properties; [Au(C boolean AND N boolean AND C)(IMe)]CF3SO3 (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model.
引用
收藏
页码：3893 / 3895
页数：3
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