Sex Differences in Heart Failure

被引：81

作者：

Lala, Anuradha ^{[1
,2
]}

Tayal, Upasana ^{[3
]}

Hamo, Carine E. ^{[1
,2
]}

Youmans, Quentin ^{[4
]}

Al-Khatib, Sana M. ^{[5
]}

Bozkurt, Biykem ^{[6
]}

Davis, Melinda B. ^{[7
]}

Januzzi, James ^{[8
,9
]}

Mentz, Robert ^{[5
]}

Sauer, Andrew ^{[10
]}

Walsh, Mary Norine ^{[11
]}

Yancy, Clyde ^{[4
]}

Gulati, Martha ^{[12
]}

机构：

[1] Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, 1 Gustave Levy Pl,Box 1030, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, 1 Gustave Levy Pl,Box 1030, New York, NY 10029 USA

[3] Royal Brompton Hosp, Imperial Coll London, Natl Heart Lung Inst, London, England

[4] Northwestern Univ, Dept Med, Chicago, IL 60611 USA

[5] Duke Univ, Med Ctr, Div Cardiol, Duke Clin Res Inst, Durham, NC 27710 USA

[6] Baylor Coll Med, Michael E DeBakey VA Med Ctr, Cardiovasc Res Inst, Winters Ctr Heart Failure,Cardiol, Houston, TX 77030 USA

[7] Univ Michigan, Dept Internal Med, Div Cardiovasc Med, Ann Arbor, MI 48109 USA

[8] Massachusetts Gen Hosp, Cardiol Div, Boston, MA 02114 USA

[9] Baim Inst Clin Res, Trial Design, Brookline, MA USA

[10] Univ Kansas, Med Ctr, Dept Cardiovasc Med, Kansas City, KS 66103 USA

[11] Ascens St Vincent Heart Ctr, Indianapolis, IN USA

[12] Univ Arizona, Phoenix, AZ USA

来源：

JOURNAL OF CARDIAC FAILURE | 2022年 / 28卷 / 03期

关键词：

Heart failure; women; sex differences; cardiovascular disease; VENTRICULAR ASSIST DEVICES; IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS; CARDIAC RESYNCHRONIZATION THERAPY; PRESERVED EJECTION FRACTION; BREAST-CANCER PATIENTS; PERIPARTUM CARDIOMYOPATHY; MYOCARDIAL-INFARCTION; GENDER-DIFFERENCES; LIFETIME RISK; CARDIOVASCULAR-DISEASE;

D O I：

10.1016/j.cardfail.2021.10.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure (HF) continues to be a major contributor of morbidity and mortality for men and women alike, yet how the predisposition for, course and management of HF differ between men and women remains underexplored. Sex differences in traditional risk factors as well as sex-specific risk factors influence the prevalence and manifestation of HF in unique ways. The pathophysiology of HF differs between men and women and may explain sex-specific differences in clinical presentation and diagnosis. This in turn, contributes to variation in response to both pharmacologic and device/surgical therapy. This review examines sex-specific differences in HF spanning prevalence, risk factors, pathophysiology, presentation, and therapies with a specific focus on highlighting gaps in knowledge with calls to action for future research efforts.

引用

页码：477 / 498

页数：22

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