Chemical Composition and Evaluation Preliminary of Antileishmanial Activity in vitro of Essential Oil from Leaves of Eugenia pitanga, A Native Species of Southern of Brazil

被引：6

作者：

Kauffmann, Carla ^{[1
]}

Ethur, Eduardo Miranda ^{[2
]}

Arossi, Kelen ^{[1
]}

Hoehne, Lucelia ^{[2
]}

de Freitas, Elisete Maria ^{[1
]}

de Carvalho Machado, Gerzia Maria ^{[3
]}

do Canto Cavalheiro, Marilene Marcuzzo ^{[3
]}

Flach, Adriana ^{[4
]}

Mendonca Alves da Costa, Luiz Antonio ^{[4
]}

Baggio Gnoatto, Simone Cristina ^{[5
]}

机构：

[1] Ctr Univ UNIVATES, Ctr Ciencias Biol & Saude, Avelino Tallini 171, BR-95914014 Lajeado, RS, Brazil

[2] Ctr Univ UNIVATES, Ctr Ciencias Exatas & Tecnol, Avelino Tallini 171, BR-95914014 Lajeado, RS, Brazil

[3] Inst Oswaldo Cruz FIOCRUZ, Lab Bioquim Tripanosomatideos, Pavilhao Leonidas Deane,Sala 402 A,Av Brasil 4365, BR-21040360 Rio De Janeiro, RJ, Brazil

[4] Univ Fed Roraima, Dept Quim, Av Cap Ene Garcez 2413,Bl 3, BR-69304000 Boa Vista, RR, Brazil

[5] Univ Fed Rio Grande do Sul, Fac Farm, Lab Fitoquim & Sintese Organ, Av Ipiranga 2752, BR-90610000 Porto Alegre, RS, Brazil

来源：

JOURNAL OF ESSENTIAL OIL BEARING PLANTS | 2017年 / 20卷 / 02期

关键词：

Antileishmanial activity; Eugenia pitanga; Myrtaceae; Leishmania amazonensis; Essential oil; CUMINI L. SKEELS; LEISHMANICIDAL ACTIVITY; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; AMAZONENSIS; MYRTACEAE; MEDICINE; LIPPIA;

D O I：

10.1080/0972060X.2017.1281767

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eugenia pitanga (O.Berg) Nied., Myrtaceae, popularly known as pitanga-do-campo, is a species native from Pampa biome, in southern of Brazil and is popularly used as antidiarrheal, anti-rheumatic, stimulant and febrifuge. The aim of this work was to determine the chemical composition of essential oil from fresh leaves of Eugenia pitanga (O.Berg) Nied. Preliminaries data about antileishmanial activity in vitro of essential oil against promastigotes forms of Leishmania amazonensis are presented. The method to determine the chemical composition of the essential oil from fresh leaves of E. pitanga (EoEp) was gas chromatography-mass spectrometry. EoEp was assayed in vitro for antileishmanial activity against promastigotes of Leishmania amazonensis. The EoEp comprised 57 components and was rich in oxygenated sesquiterpenes (72.97 %) with spathulenol (15.34 %), globulol (10.93 %) and (2E,6E) methyl farnesoate (7.40 %) as the major constituents. EoEp was effective against L. amazonensis promastigotes with IC50 value of 6.10 +/- 1.80 mu g/mL. This work reports for the first time the composition of essential oil from leaves of E. pitanga from Pampa Biome, and it suggests the importance of continuing the studies in order to explain the antileishmanial activity.

引用

页码：559 / 569

页数：11

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