CRISPR-Cas9 Probing of Infectious Diseases and Genetic Disorders

被引:1
|
作者
Ramalingam, Sivaprakash [1 ]
Thangavel, Saravanabhavan [2 ]
机构
[1] IGIB, CSIR, Mathura Rd, New Delhi, India
[2] CSCR, Christian Med Coll Campus, Vellore, Tamil Nadu, India
来源
INDIAN JOURNAL OF PEDIATRICS | 2019年 / 86卷 / 12期
关键词
Targeted genome engineering/editing; Zinc finger nucleases; Transcription activator-like effector nucleases; Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated systems (Cas9); Infectious diseases and genetic disorders; PLURIPOTENT STEM-CELLS; GENERATION;
D O I
10.1007/s12098-019-03037-9
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The ability to precisely change the deoxyribonucleic acid (DNA) bases at specific sites offers tremendous advantages in the field of molecular biology and medical biotechnology. Identification of Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), revelation of its role in prokaryotic adaptive immunity and subsequent conversion into genome and epigenome engineering system are the landmark research progresses of the decade. The possibilities of deciphering the molecular mechanisms of the disease, identifying the disease targets, generating the disease models, validating the drug targets, developing resistance to the infection and correcting the genotype have brought off much enthusiasm in the field of infectious diseases and genetic disorders. This review focuses on CRISPR/Cas9's impact in the field of infection and genetic disorders.
引用
收藏
页码:1131 / 1135
页数:5
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