Applications of CRISPR-Cas9 in The Prevention and Control of Viral Infectious Diseases

被引:0
|
作者
Li Gen [1 ]
Liu Jun-Hua [1 ]
He Li-Jie [2 ]
Yin Xiu-Shan [1 ,3 ]
机构
[1] Shenyang Univ Chem Technol, Coll Pharmaceut & Biol Engn, Shenyang 110142, Liaoning, Peoples R China
[2] Peoples Hosp Liaoning Prov, Shenyang 110016, Liaoning, Peoples R China
[3] Karolinska Inst MTC, Sci Life Lab, Tomtebodavag 23A Gammas, S-17165 Solna, Sweden
关键词
viral infectious diseases; gene editing techniques; CRISPR-Cas9; viral vectors; clinical trials; HEPATITIS-B-VIRUS; EPSTEIN-BARR-VIRUS; RNA-GUIDED ENDONUCLEASE; INHIBIT HIV-1 REPLICATION; HUMAN-PAPILLOMAVIRUS E6; PLURIPOTENT STEM-CELLS; HERPES-SIMPLEX VIRUSES; EPHRIN RECEPTOR A2; LATENT HIV-1; CRISPR/CAS9; SYSTEM;
D O I
10.16476/j.pibb.2018.0032
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Infectious diseases make up an important threat to human health and there is an urgent need for new treatments to reduce morbidity and mortality caused by acute viral infections such as rhinovirus and dengue virus, and chronic viral infections such as human immunodeficiency virus-1 and hepatitis B virus. With the development of molecular biology technology, gene-editing technology targeting sequence-specific loci has become a powerful tool for the treatment of infectious diseases. Among them, the regular clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated protein 9 (Cas9) is widely used in cell lines and animal models because of its high efficiency, convenience and high specificity, which has become a promising model for the treatment of new infectious diseases. Currently, feasibility studies of the use of viral and non-viral vectors to deliver Cas9 into cells in the form of DNA, mRNA or protein and clinical trials assessing the in vivo applicability of CRISPR-Cas9 are under way. In this review, we outline the principles of CRISPR-Cas9, the latest research advances in the treatment of infectious diseases, the challenges and possible solutions to the technology, and look further into its future direction.
引用
收藏
页码:1006 / 1025
页数:20
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