Identification of immunogenic MHC class II tyrosinase-derived peptides using HLA-DR1 and HLA-DR4 transgenic mice

被引：1

作者：

Horton, R. B. V. ^{[1
]}

Laversin, S. A. S. ^{[1
]}

Reeder, S. P. ^{[1
]}

Rees, R. C. ^{[1
]}

McArdle, S. E. B. ^{[1
]}

机构：

[1] Nottingham Trent Univ, Sch Biomed & Nat Sci, Interdisciplinary Biomed Res Ctr, Nottingham NG11 8NS, England

来源：

PROTEIN AND PEPTIDE LETTERS | 2007年 / 14卷 / 05期

关键词：

MHC class II; peptides; CD4(+) T cells; vitamin E; dendritic cells;

D O I：

10.2174/092986607780782768

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The immunogenicity of "novel" MART-1 and Tyrosinase class-Il peptides was assessed in transgenic mice. Tyrosinase(141-161) peptide was found to be immunogenic and endogenously processed in the HLA-DR beta 1*0101 and HLA-DR beta 1*0401 transgenic mice with peptide specific production of IFN gamma or IL-5 respectively. The MART-1(29-43) Peptide was only found immunogenic in HLA-DR beta 1*0101 mice.

引用

页码：455 / 460

页数：6

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