Identification of immunogenic MHC class II tyrosinase-derived peptides using HLA-DR1 and HLA-DR4 transgenic mice

被引：1
|
作者：
Horton, R. B. V. [1 ]
Laversin, S. A. S. [1 ]
Reeder, S. P. [1 ]
Rees, R. C. [1 ]
McArdle, S. E. B. [1 ]
机构：
[1] Nottingham Trent Univ, Sch Biomed & Nat Sci, Interdisciplinary Biomed Res Ctr, Nottingham NG11 8NS, England
来源：
PROTEIN AND PEPTIDE LETTERS | 2007年 / 14卷 / 05期
关键词：
MHC class II; peptides; CD4(+) T cells; vitamin E; dendritic cells;
D O I：
10.2174/092986607780782768
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The immunogenicity of "novel" MART-1 and Tyrosinase class-Il peptides was assessed in transgenic mice. Tyrosinase(141-161) peptide was found to be immunogenic and endogenously processed in the HLA-DR beta 1*0101 and HLA-DR beta 1*0401 transgenic mice with peptide specific production of IFN gamma or IL-5 respectively. The MART-1(29-43) Peptide was only found immunogenic in HLA-DR beta 1*0101 mice.
引用
收藏
页码：455 / 460
页数：6
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