Determination of stability constants for alkanol/α-cyclodextrin inclusion complexes using the surface tension method

The stability constants for the inclusion of alkanols with alpha-cyclodextrin (alpha-CD) in aqueous solution have been determined using the surface tension method. Data analyses assuming 1 : 1 stoichiometry were applied to estimate the stability constants of these complexes. The stability constants obtained using this method were in reasonable agreement with the corresponding values in the literature. Chemically modified alpha-CDs could not be used in this method because those CDs themselves have surface activity. In addition, the relation between the stability constants and the carbon number of alkanols is discussed.