Is there an association between neurocognitive performance and medication adherence in first episode psychosis?

被引:20
|
作者
Lepage, Martin
Bodnar, Michael
Joober, Ridha
Malla, Ashok
机构
[1] McGill Univ, Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada
[2] McGill Univ, Dept Psychiat, Montreal, PQ, Canada
关键词
cognition; medication adherence; medication compliance; psychosis; schizophrenia; 1ST-EPISODE PSYCHOSIS; SCHIZOAFFECTIVE DISORDER; SCHIZOPHRENIA; PREDICTORS; DISCONTINUATION; INSIGHT; SYMPTOMS; OUTCOMES; TIME;
D O I
10.1111/j.1751-7893.2010.00174.x
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Aim: Medication adherence is a determining factor for symptomatic remission and relapse prevention following a first episode of psychosis (FEP). Neurocognitive abilities have received only scant attention so far as a risk factor for poor adherence but significant impairments with memory and/or planning abilities could play a role. We examined early medication adherence following admission to a specialized clinical programme for FEP. Method: One hundred sixty FEP participants and 35 healthy controls completed an exhaustive neurocognitive assessment. FEP participants were categorized as a function of their medication adherence at 6 months into poor (n = 34), partial (n = 27) and full (n = 99) adherence, respectively. Domain-specific and global measures of cognitive ability were examined. Results: No measure of neurocognition could significantly discriminate amongst the three medication adherence groups. Conclusion: These results suggest no strong associations between neurocognitive abilities and medication adherence in first episode of psychosis.
引用
收藏
页码:189 / 195
页数:7
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