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Correlation of neurological soft signs and neurocognitive performance in first episode psychosis
被引:9
|作者:
Arabzadeh, Somaye
[1
]
Amini, Homayoun
[1
,2
]
Tehrani-Doost, Mehdi
[1
]
Sharifi, Vandad
[1
,2
]
Noroozian, Maryam
[1
,2
]
Rahiminejad, Fatemeh
[1
]
机构:
[1] Univ Tehran Med Sci, Roozbeh Hosp, Dept Psychiat, Tehran, Iran
[2] Univ Tehran Med Sci, Psychiat & Psychol Res Ctr, Tehran, Iran
关键词:
Executive function;
Neuropsychological tests;
Neurologic signs;
Psychotic disorders;
Schizophrenia;
Working memory;
WORKING-MEMORY DEFICITS;
FORMAL THOUGHT-DISORDER;
RISK MENTAL STATE;
1ST-EPISODE SCHIZOPHRENIA;
NEUROPSYCHOLOGICAL PERFORMANCE;
COGNITIVE IMPAIRMENT;
ABNORMALITIES;
ONSET;
PSYCHOPATHOLOGY;
ADOLESCENTS;
D O I:
10.1016/j.psychres.2014.07.044
中图分类号:
R749 [精神病学];
学科分类号:
100205 ;
摘要:
Neurological soft signs and neurocognitive impairments are commonly observed in first episode psychosis but the correlation of these factors remains controversial. Here, we evaluated 30 patients with remitted first episode psychosis and 30 healthy controls for the presence and severity of neurological soft signs (using the Neurological Evaluation Scale - NES) and for neurocognitive impairments (using seven subtests of the Cambridge Neuropsychological Test Automated Battery - CANTAB). NES score was higher in patients compared to controls. Neurocognitive impairment was evident in patients in the following domains: working memory, spatial recognition memory, attention set shifting, planning and inhibition. The NES revealed significant correlations with spatial working memory performance and Intra-Extra Dimensional Set Shifting (as a component of executive function). These correlations were observed both in patients and in controls. Planning and inhibition showed correlation with the total NES score and the sequencing of complex motor acts in both groups. In addition, spatial span and spatial recognition memory showed significant correlation with total NES score and the sequencing of complex motor acts in controls. The correlation between sequencing of complex motor acts and specific domains of neurocognitive tasks suggests that similar neuroanatomical substrates might be implicated in these processes. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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页码:81 / 88
页数:8
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