Angiotensin-Converting Enzyme Gene Polymorphism in Overweight and Obese Turkish Patients with Insulin Resistance

被引：17
|
作者：
Akin, Fulya [1 ]
Turgut, Sebahat [2 ]
Bastemir, Mehmet [1 ]
Turgut, Gunfer [2 ]
Kursunluoglu, Raziye [2 ]
Karasu, Ugur [3 ]
Guclu, Aydin [3 ]
机构：
[1] Pamukkale Univ, Dept Endocrinol & Metab, Fac Med, TR-20070 Denizli, Turkey
[2] Pamukkale Univ, Dept Physiol, Fac Med, TR-20070 Denizli, Turkey
[3] Pamukkale Univ, Dept Internal Med, Fac Med, TR-20070 Denizli, Turkey
来源：
DNA AND CELL BIOLOGY | 2010年 / 29卷 / 04期
关键词：
CORONARY-HEART-DISEASE; PLASMA ACE LEVELS; INSERTION/DELETION POLYMORPHISM; DELETION POLYMORPHISM; I/D POLYMORPHISM; ADIPOSE-TISSUE; GLUCOSE-INTOLERANCE; METABOLIC SYNDROME; DIABETES-MELLITUS; ASSOCIATION;
D O I：
10.1089/dna.2009.0934
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The aim of this study was to analyze the distribution of the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in obese Turkish patients with insulin resistance (IR). Sixty-two obese Turkish patients with IR were enrolled in this study. One hundred healthy people without IR were recruited as the control group. ACE amplification was performed by polymerase chain reaction. The frequency of the DD genotype was significantly higher in obese patients with IR than in control subjects. Of sixty-two patients, 1 (1.6%) had an II genotype, 22 (35.5%) had an ID genotype, and 39 (62.9%) had a DD genotype. The frequency of the I allele in the patient group was significantly lower than in controls. We found that the frequency of the DD genotype was higher in obese Turkish patients with IR. ACE gene I/D polymorphism may be associated with obesity in the Turkish population.
引用
收藏
页码：207 / 212
页数：6
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