Resuscitation-promoting factors are important determinants of the pathophysiology in Mycobacterium tuberculosis infection

被引：61
|
作者：
Rosser, Andrew [1 ,2 ]
Stover, Cordula [1 ]
Pareek, Manish [1 ,2 ]
Mukamolova, Galina V. [1 ]
机构：
[1] Univ Leicester, Dept Infect Immun & Inflammat, Leicester, Leics, England
[2] Univ Hosp Leicester NHS Trust, Dept Infect & Trop Med, Leicester, Leics, England
来源：
CRITICAL REVIEWS IN MICROBIOLOGY | 2017年 / 43卷 / 05期
基金：
英国生物技术与生命科学研究理事会; 美国国家卫生研究院;
关键词：
Resuscitation promoting factors; Mycobacterium tuberculosis; tuberculosis; pathogenesis; Rpf; T-CELL IMMUNITY; LATENT TUBERCULOSIS; BACTERIAL-GROWTH; IN-VITRO; VACCINE DEVELOPMENT; MULTIPLE DELETIONS; RELEASE ASSAYS; RPF PROTEINS; ANTIGENS; DIAGNOSIS;
D O I：
10.1080/1040841X.2017.1283485
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Resuscitation promoting factors (Rpf) are peptidoglycan-hydrolyzing enzymes that are pivotal in the resuscitation of quiescent actinobacteria including Mycobacterium tuberculosis. From the published data, it is clear that Rpf are required for the resuscitation of non-replicating bacilli and pathogenesis in murine infection model of tuberculosis, although their direct influence on human Mycobacterium tuberculosis infection is ill-defined. In this review, we describe the progress in the understanding of the roles that Rpf play in human tuberculosis pathogenesis and importance of bacilli dependent upon Rpf for growth for the outcome of human tuberculosis. We outline how this research is opening up important opportunities for the diagnosis, treatment and prevention of human disease, progress in which is essential to attain the ultimate goal of tuberculosis eradication.
引用
收藏
页码：621 / 630
页数：10
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