New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk

被引：34
|
作者：
Li, Yan [1 ,3 ]
Yili, Abulimiti [1 ,2 ]
Li, Jun [2 ]
Muhamat, Aziz [2 ,3 ]
Aisa, Haji Akber [1 ,2 ]
机构：
[1] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plants Resources & Chem Arid Zone, Beijing South Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China
[2] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Beijing South Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100039, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Fritillaria pallidiflora; Isosteroidal alkaloid; Yibeinones A-D; Tracheal relaxant effect; STEROIDAL ALKALOIDS; CHEMICAL-CONSTITUENTS; MUSCARINIC RECEPTORS;
D O I：
10.1016/j.bmcl.2016.03.001
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new isosteroidal alkaloids, yibeinones A-D (1-4), along with four known ones, imperialine-3 beta-D-glucoside (5), imperialine (6), imperialine beta-N-oxide (7), and dongbeinine (8), were isolated from the bulbs of Fritillaria pallidiflora. Their structures were confirmed on the basis of extensive spectroscopic analysis or comparison with the data in the literatures (known compounds). Compounds 2, 3, 4, and 6 showed an apparent concentration-dependant relaxation of isolated tracheal preparation, amongst 3 and 6 exhibited significant effects with pA(2) values of 6.19 +/- 0.02 and 8.41 +/- 0.10, and EC50 values of 0.65 +/- 0.02 mu mol L-1 and 4.40 +/- 0.90 nmol L-1, respectively. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1983 / 1987
页数：5
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