Targeting CD2 for immunotherapy: Results of a phase 1 trial with a LFA-3/IgG Fe fusion protein.

被引：0
|
作者：
Magilavy, D
Norman, P
Majeau, G
Knox, S
Winkler, G
MacLellan, S
Sartori, L
Cooney, M
Meier, W
Hochman, P
Rogge, M
机构：
[1] Biogen Inc, Cambridge, MA 02142 USA
[2] UMDS, Guys Hosp, London, England
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 1998年 / 110卷 / 04期
关键词：
D O I：
暂无
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
引用
收藏
页码：682 / 682
页数：1
相关论文
共 50 条
  • [41] ANALYSIS OF THE LFA-1 AND CD2/LFA-3 PATHWAYS OF ANTIGEN-INDEPENDENT ADHESION USED BY HUMAN CYTOTOXIC T-CELL CLONES
    SHAW, S
    LUCE, GEG
    DUSTIN, M
    SANDERS, M
    SPRINGER, TA
    FEDERATION PROCEEDINGS, 1987, 46 (03) : 919 - 919
  • [42] Selective T cell reduction in scleroderma lung disease, using LFA-3/IgG1 human fusion protein (Alefacept).
    White, B
    Choi, J
    Wigley, F
    Wise, R
    ARTHRITIS AND RHEUMATISM, 2002, 46 (09): : S202 - S202
  • [43] SPECIFIC DOWN-REGULATION OF PROLIFERATIVE T-CELL ALLORESPONSIVENESS BY INTERFERENCE WITH CD2/LFA-3 AND LFA-1/ICAM-1 IN-VITRO
    BOHMIG, GA
    KOVARIK, J
    HOLTER, W
    POHANKA, E
    ZLABINGER, GJ
    JOURNAL OF IMMUNOLOGY, 1994, 152 (08): : 3720 - 3728
  • [44] PRIMARY STRUCTURE OF LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN-3 (LFA-3) - THE LIGAND OF THE LYMPHOCYTE-T CD2 GLYCOPROTEIN
    WALLNER, BP
    FREY, AZ
    TIZARD, R
    MATTALIANO, RJ
    HESSION, C
    SANDERS, ME
    DUSTIN, ML
    SPRINGER, TA
    JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 166 (04): : 923 - 932
  • [45] PURIFIED LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-3 (LFA-3) ACTIVATES HUMAN THYMOCYTES VIA THE CD2 PATHWAY
    DENNING, SM
    DUSTIN, ML
    SPRINGER, TA
    SINGER, KH
    HAYNES, BF
    JOURNAL OF IMMUNOLOGY, 1988, 141 (09): : 2980 - 2985
  • [46] THE POTENTIATION OF LYMPHOCYTE-B RESPONSES THROUGH CD2/LFA-3 INTERACTIONS INVOLVING ERYTHROCYTES IS IL2 INDEPENDENT
    TRIFILETTI, R
    LAVIA, M
    VIRELLA, G
    CELLULAR IMMUNOLOGY, 1989, 124 (02) : 359 - 367
  • [47] Cognate interactions mediated by a recombinant LFA-3/IgG1 fusion induce CD16 signaling and granzyme B dependent apoptosis of activated CD2+cells.
    da Silva, AJ
    Brickelmaier, M
    Majeau, G
    Li, ZF
    Hochman, P
    JOURNAL OF LEUKOCYTE BIOLOGY, 2001, : 55 - 55
  • [48] INTERACTION BETWEEN CD2 AND LFA-3 MEDIATES ROSETTING OF ACTIVATED HUMAN LYMPHOCYTES-T WITH HUMAN-E
    PLUNKETT, ML
    SANDER, ME
    SELVARAJ, P
    DUSTIN, ML
    SHAW, S
    SPRINGER, TA
    FEDERATION PROCEEDINGS, 1987, 46 (03) : 471 - 471
  • [49] Visualization of CD2 interaction with LFA-3 and determination of the two-dimensional dissociation constant for adhesion receptors in a contact area
    Dustin, ML
    Ferguson, LM
    Chan, PY
    Springer, TA
    Golan, DE
    JOURNAL OF CELL BIOLOGY, 1996, 132 (03): : 465 - 474
  • [50] HUMAN CYTOTOXIC T-CELLS ADHERE TO POTENTIAL TARGETS BY 2 ANTIGEN-INDEPENDENT PATHWAYS - CD2 BINDING TO LFA-3 OR LFA-1 BINDING TO AN UNDEFINED LIGAND
    SHAW, S
    LUCE, GG
    SPRINGER, TA
    PLUNKETT, ML
    QUINONES, R
    GRESS, RE
    SANDERS, ME
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1987, : 207 - 207
12345