Transforming Growth Factor-β and Long Non-coding RNA in Renal Inflammation and Fibrosis

被引：21
|
作者：
Gu, Yue-Yu [1 ,2 ]
Dou, Jing-Yun [1 ,3 ]
Huang, Xiao-Ru [2 ,4 ]
Liu, Xu-Sheng [1 ]
Lan, Hui-Yao [2 ,5 ]
机构：
[1] Guangzhou Univ Chinese Med, Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Dept Nephrol, Guangdong Prov Hosp Chinese Med,Affiliated Hosp 2, Guangzhou, Peoples R China
[2] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Dept Med & Therapeut, Guangzhou, Peoples R China
[3] Weihai Hosp Tradit Chinese Med, Dept Nephrol, Weihai, Peoples R China
[4] Guangdong Acad Med Sci, Guangdong Hong Kong Joint Lab Immun & Genet Chron, Guangdong Prov Peoples Hosp, Guangzhou, Peoples R China
[5] Chinese Univ Hong Kong, Hong Kong Joint Lab Immun & Genet Chron Kidney Di, Guangzhou, Peoples R China
来源：
FRONTIERS IN PHYSIOLOGY | 2021年 / 12卷
基金：
中国国家自然科学基金;
关键词：
long non-coding RNA; renal fibrosis; inflammation; TGF-β SMADs; molecular therapy; ARISTOLOCHIC ACID NEPHROPATHY; TO-MESENCHYMAL TRANSITION; TUBULAR EPITHELIAL-CELLS; MEDIATED GENE-TRANSFER; CHRONIC KIDNEY-DISEASE; TGF-BETA; DIABETIC-NEPHROPATHY; THERAPEUTIC TARGETS; MYOFIBROBLAST TRANSITION; LATENT TGF-BETA-1;
D O I：
10.3389/fphys.2021.684236
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Renal fibrosis is one of the most characterized pathological features in chronic kidney disease (CKD). Progressive fibrosis eventually leads to renal failure, leaving dialysis or allograft transplantation the only clinical option for CKD patients. Transforming growth factor-beta (TGF-beta) is the key mediator in renal fibrosis and is an essential regulator for renal inflammation. Therefore, the general blockade of the pro-fibrotic TGF-beta may reduce fibrosis but may risk promoting renal inflammation and other side effects due to the diverse role of TGF-beta in kidney diseases. Long non-coding RNAs (lncRNAs) are RNA transcripts with more than 200 nucleotides and have been regarded as promising therapeutic targets for many diseases. This review focuses on the importance of TGF-beta and lncRNAs in renal inflammation, fibrogenesis, and the potential applications of TGF-beta and lncRNAs as the therapeutic targets and biomarkers in renal fibrosis and CKD are highlighted.
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页数：13
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