Enhancement of resolution of DNA on silylated mica using atomic force microscopy

被引：13
|
作者：
Tang, J [1 ]
Li, JW [1 ]
Wang, C [1 ]
Bai, CL [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
来源：
JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B | 2000年 / 18卷 / 04期
关键词：
D O I：
10.1116/1.1305270
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
It is demonstrated that the mica surface covered with a nanometer-thick, well connected silane film can appreciably improve the lateral resolution of DNA molecules in comparison with that on bare mica using atomic force microscopy. A typical value width of 4 nm can be obtained. We propose that the nanometer dimensioned porous surface provides an approach to eliminate the hydrated salt layer associated with the condensation of DNA strands, and leads to the enhancement of lateral resolution. (C) 2000 American Vacuum Society. [S0733-211X(00)02904-8].
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页码：1858 / 1860
页数：3
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