A Wacky Bridge to mTORC1 Dimerization

被引：4

作者：

Montagne, Jacques ^{[1
]}

机构：

[1] Univ Paris 11, CEA, CNRS, Inst Integrat Biol Cell I2BC,UMR 9198, F-91190 Gif Sur Yvette, France

来源：

DEVELOPMENTAL CELL | 2016年 / 36卷 / 02期

关键词：

RAPAMYCIN; COMPLEX; GROWTH; TARGET; DTOR;

D O I：

10.1016/j.devcel.2016.01.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The activity of the mTORC1 protein complex depends on multiple metabolic inputs that regulate dimerization, recruitment to the lysosome, and activation. In this issue of Developmental Cell, David-Morrison et al. (2016) show that the Drosophila protein Wacky and its mammalian counterpart WAC act as adaptors in the process of mTORC1 dimerization.

引用

页码：129 / 130

页数：2

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