Generation and characterization of an induced pluripotent stem cell line (FJMUNi001-A) from a patient with Duchenne muscular dystrophy carrying c.4518+512 T > A variant in the DMD gene

被引：0
|
作者：
Jin, Ming [1 ]
Wang, Danni [2 ]
Li, Guoling [3 ]
Lin, Jiajia [1 ]
Lin, Xiang [1 ]
Wang, Ning [1 ]
机构：
[1] Fujian Med Univ, Affiliated Hosp 1, Fujian Inst Neurol, Dept Neurol, Fuzhou, Peoples R China
[2] Xiamen Univ, Affiliated Hosp 1, Sch Med, Dept Neurol, Xiamen, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, CAS Ctr Excellence Brain Sci & Intelligence Techno, Shanghai, Peoples R China
来源：
STEM CELL RESEARCH | 2022年 / 60卷
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.scr.2022.102718
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Duchenne muscular dystrophy (DMD) is an X-linked recessive degenerative disease characterized by progressive weakness of limbs. In this study, we generated an induced pluripotent stem cell line from a DMD patient's dermal fibroblasts with non-integrating Sendai virus. The patient carried a rare c.4518 + 512 T > A variant in the DMD gene. This iPSC line displayed normal iPSC morphology, karyotypes and pluripotency expression markers, and also can be differentiated into the three germ layers.
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页数：4
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