Disrupted Sleep in Narcolepsy: Exploring the Integrity of Galanin Neurons in the Ventrolateral Preoptic Area

被引：3
|
作者：
Gavrilov, Yury V. [1 ,2 ,3 ]
Ellison, Brian A. [1 ]
Yamamoto, Mihoko [1 ]
Reddy, Hasini [4 ]
Haybaeck, Johannes [5 ]
Mignot, Emmanuel [6 ]
Baumann, Christian R. [1 ,2 ]
Scammell, Thomas E. [1 ]
Valko, Philipp O. [1 ,2 ]
机构：
[1] Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA
[2] Univ Zurich, Univ Zurich Hosp, Dept Neurol, Frauenklinikstr 26, CH-8091 Zurich, Switzerland
[3] Inst Expt Med, Dept Gen Pathol & Pathol Physiol, St Petersburg, Russia
[4] Beth Israel Deaconess Med Ctr, Dept Neuropathol, Boston, MA 02215 USA
[5] Med Univ Graz, Inst Pathol, Dept Neuropathol, Graz, Austria
[6] Stanford Univ, Ctr Narcolepsy, Dept Psychiat, Palo Alto, CA 94304 USA
来源：
SLEEP | 2016年 / 39卷 / 05期
基金：
瑞士国家科学基金会;
关键词：
galanin; narcolepsy; sleep fragmentation; ventrolateral preoptic area; REM-SLEEP; NIGHTTIME SLEEP; NUCLEUS; CATAPLEXY; HYPOTHALAMUS; NUMBERS;
D O I：
10.5665/sleep.5754
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Study Objectives: To examine the integrity of sleep-promoting neurons of the ventrolateral preoptic nucleus (VLPO) in postmortem brains of narcolepsy type 1 patients. Methods: Postmortem examination of five narcolepsy and eight control brains. Results: VLPO galanin neuron count did not differ between narcolepsy patients (11,151 +/- 3,656) and controls (13,526 +/- 9,544). Conclusions: A normal number of galanin-immunoreactive VLPO neurons in narcolepsy type 1 brains at autopsy suggests that VLPO cell loss is an unlikely explanation for the sleep fragmentation that often accompanies the disease.
引用
收藏
页码：1059 / 1062
页数：4
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