Disrupted Sleep in Narcolepsy: Exploring the Integrity of Galanin Neurons in the Ventrolateral Preoptic Area

被引：3

作者：

Gavrilov, Yury V. ^{[1
,2
,3
]}

Ellison, Brian A. ^{[1
]}

Yamamoto, Mihoko ^{[1
]}

Reddy, Hasini ^{[4
]}

Haybaeck, Johannes ^{[5
]}

Mignot, Emmanuel ^{[6
]}

Baumann, Christian R. ^{[1
,2
]}

Scammell, Thomas E. ^{[1
]}

Valko, Philipp O. ^{[1
,2
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA

[2] Univ Zurich, Univ Zurich Hosp, Dept Neurol, Frauenklinikstr 26, CH-8091 Zurich, Switzerland

[3] Inst Expt Med, Dept Gen Pathol & Pathol Physiol, St Petersburg, Russia

[4] Beth Israel Deaconess Med Ctr, Dept Neuropathol, Boston, MA 02215 USA

[5] Med Univ Graz, Inst Pathol, Dept Neuropathol, Graz, Austria

[6] Stanford Univ, Ctr Narcolepsy, Dept Psychiat, Palo Alto, CA 94304 USA

来源：

SLEEP | 2016年 / 39卷 / 05期

基金：

瑞士国家科学基金会;

关键词：

galanin; narcolepsy; sleep fragmentation; ventrolateral preoptic area; REM-SLEEP; NIGHTTIME SLEEP; NUCLEUS; CATAPLEXY; HYPOTHALAMUS; NUMBERS;

D O I：

10.5665/sleep.5754

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Study Objectives: To examine the integrity of sleep-promoting neurons of the ventrolateral preoptic nucleus (VLPO) in postmortem brains of narcolepsy type 1 patients. Methods: Postmortem examination of five narcolepsy and eight control brains. Results: VLPO galanin neuron count did not differ between narcolepsy patients (11,151 +/- 3,656) and controls (13,526 +/- 9,544). Conclusions: A normal number of galanin-immunoreactive VLPO neurons in narcolepsy type 1 brains at autopsy suggests that VLPO cell loss is an unlikely explanation for the sleep fragmentation that often accompanies the disease.

引用

页码：1059 / 1062

页数：4

共 50 条

[1] Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice
Kroeger, Daniel
Absi, Gianna
Gagliardi, Celia
Bandaru, Sathyajit S.
Madara, Joseph C.
Ferrari, Loris L.
Arrigoni, Elda
Munzberg, Heike
Scammell, Thomas E.
Saper, Clifford B.
Vetrivelan, Ramalingam
NATURE COMMUNICATIONS, 2018, 9
[2] Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice
Daniel Kroeger
Gianna Absi
Celia Gagliardi
Sathyajit S. Bandaru
Joseph C. Madara
Loris L. Ferrari
Elda Arrigoni
Heike Münzberg
Thomas E. Scammell
Clifford B. Saper
Ramalingam Vetrivelan
Nature Communications, 9
[3] Estradiol modulates activity of the sleep neurons in the ventrolateral preoptic area.
Schwarz, JM
Mong, JA
HORMONES AND BEHAVIOR, 2004, 46 (01) : 101 - 101
[4] Activation of ventrolateral preoptic neurons during sleep
Sherin, JE
Shiromani, PJ
McCarley, RW
Saper, CB
SCIENCE, 1996, 271 (5246) : 216 - 219
[5] Activation of ventrolateral preoptic neurons during sleep
Science, 5246 (216):
[6] Astrocytes in the Ventrolateral Preoptic Area Promote Sleep
Kim, Jae-Hong
Choi, In-Sun
Jeong, Ji-Young
Jang, Il-Sung
Lee, Maan-Gee
Suk, Kyoungho
JOURNAL OF NEUROSCIENCE, 2020, 40 (47): : 8994 - 9011
[7] Estradiol suppresses activation of putative sleep neurons in the ventrolateral preoptic area of the adult rat
Mong, Jessica A.
JOURNAL OF WOMENS HEALTH, 2006, 15 (06) : 691 - 691
[8] Nicotinic enhancement of the noradrenergic inhibition of sleep-promoting neurons in the ventrolateral preoptic area
Saint-Mleux, B
Eggermann, E
Bisetti, A
Bayer, L
Machard, D
Jones, BE
Mühlethaler, M
Serafin, M
JOURNAL OF NEUROSCIENCE, 2004, 24 (01): : 63 - 67
[9] Disinhibition of ventrolateral preoptic area sleep-active neurons by adenosine: A new mechanism for sleep promotion
Morairty, S
Rainnie, D
Mccarley, R
Greene, R
NEUROSCIENCE, 2004, 123 (02) : 451 - 457
[10] Maternally involved galanin neurons in the preoptic area of the rat
Melinda Cservenák
Viktor Kis
Dávid Keller
Diána Dimén
Lilla Menyhárt
Szilvia Oláh
Éva R. Szabó
János Barna
Éva Renner
Ted B. Usdin
Arpád Dobolyi
Brain Structure and Function, 2017, 222 : 781 - 798

← 1 2 3 4 5 →