toxic epidermal necrolysis (TEN);
Lyell's syndrome;
ciprofloxacin;
adverse drug reaction;
D O I:
10.1159/000245726
中图分类号:
R75 [皮肤病学与性病学];
学科分类号:
100206 ;
摘要:
Toxic epidermal necrolysis (TEN) is an uncommon fulminating mucocutaneous disease associated with marked morbidity and mortality. While sometimes idiopathic, TEN is frequently associated with drug administration. We report a well-documented fatal case of ciprofloxacin-induced TEN in a 50-year-old man treated for a bacterial infection of lower extremity venous stasis ulcers. To our knowledge, a total of 6 cases have been reported in the literature documenting an association between oral ciprofloxacin administration and TEN or Stevens-Johnson syndrome. The patient in this case had no prior medical conditions known to cause TEN, was not being treated with any medication other than ciprofloxacin (500 mg b.i.d.) and developed the clinical symptoms of TEN in a time course compatible with drug-induced TEN. This case provides strong evidence for the culpability of ciprofloxacin in the development of TEN.
机构:
Princess Alexandra Hosp, Med Oncol, Woolloongabba, Qld, AustraliaPrincess Alexandra Hosp, Med Oncol, Woolloongabba, Qld, Australia
Chow, Kar Ven Cavan
O'Leary, Connor
论文数: 0引用数: 0
h-index: 0
机构:
Princess Alexandra Hosp, Med Oncol, Woolloongabba, Qld, Australia
Queensland Univ Technol, Fac Hlth, Brisbane, Qld, AustraliaPrincess Alexandra Hosp, Med Oncol, Woolloongabba, Qld, Australia
O'Leary, Connor
Paxton-Hall, Fiona
论文数: 0引用数: 0
h-index: 0
机构:
Princess Alexandra Hosp, Med Oncol, Woolloongabba, Qld, AustraliaPrincess Alexandra Hosp, Med Oncol, Woolloongabba, Qld, Australia
Paxton-Hall, Fiona
Lambie, Duncan
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h-index: 0
机构:
Princess Alexandra Hosp, Anat Pathol, Woolloongabba, Qld, AustraliaPrincess Alexandra Hosp, Med Oncol, Woolloongabba, Qld, Australia
Lambie, Duncan
O'Byrne, Kenneth
论文数: 0引用数: 0
h-index: 0
机构:
Princess Alexandra Hosp, Med Oncol, Woolloongabba, Qld, Australia
Queensland Univ Technol, Fac Hlth, Brisbane, Qld, AustraliaPrincess Alexandra Hosp, Med Oncol, Woolloongabba, Qld, Australia
O'Byrne, Kenneth
OXFORD MEDICAL CASE REPORTS,
2022,
2022
(03):
: 112
-
114
机构:
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Wen-Yu Liu
Jia-Rong Zhang
论文数: 0引用数: 0
h-index: 0
机构:
Department of Obstetrics and Gynecology, Zhongshan Hospital, Fudan UniversityDepartment of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Jia-Rong Zhang
Xian-Ming Xu
论文数: 0引用数: 0
h-index: 0
机构:
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Xian-Ming Xu
Tian-Yi Ye
论文数: 0引用数: 0
h-index: 0
机构:
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
机构:
Clin Hosp Sveti Duh, Dept Anesthesiol Reanimatol & Intens Care, Zagreb, CroatiaClin Hosp Sveti Duh, Dept Anesthesiol Reanimatol & Intens Care, Zagreb, Croatia
Klancir, Tino
Adam, Visnja Nesek
论文数: 0引用数: 0
h-index: 0
机构:
Clin Hosp Sveti Duh, Dept Anesthesiol Reanimatol & Intens Care, Zagreb, Croatia
Josip Juraj Strossmayer Univ Osijek, Sch Med, Osijek, CroatiaClin Hosp Sveti Duh, Dept Anesthesiol Reanimatol & Intens Care, Zagreb, Croatia
Adam, Visnja Nesek
Matolic, Martina
论文数: 0引用数: 0
h-index: 0
机构:
Clin Hosp Sveti Duh, Dept Anesthesiol Reanimatol & Intens Care, Zagreb, CroatiaClin Hosp Sveti Duh, Dept Anesthesiol Reanimatol & Intens Care, Zagreb, Croatia
Matolic, Martina
Stojcic, Elvira Grizelj
论文数: 0引用数: 0
h-index: 0
机构:
Clin Hosp Sveti Duh, Dept Anesthesiol Reanimatol & Intens Care, Zagreb, CroatiaClin Hosp Sveti Duh, Dept Anesthesiol Reanimatol & Intens Care, Zagreb, Croatia
Stojcic, Elvira Grizelj
Ilic, Maja Karaman
论文数: 0引用数: 0
h-index: 0
机构:
Clin Hosp Sveti Duh, Dept Anesthesiol Reanimatol & Intens Care, Zagreb, Croatia
Josip Juraj Strossmayer Univ Osijek, Sch Med, Osijek, CroatiaClin Hosp Sveti Duh, Dept Anesthesiol Reanimatol & Intens Care, Zagreb, Croatia
机构:
Fatouma Bourguiba Univ Hosp, Dept Pharmacol, Monastir, TunisiaUniv Sousse, Fac Med Sousse, Lab Biophys Metab & Pharmacol Appliquee LR 12ES02, Sousse, Tunisia
Mansour, Khadija
Slim, Raoudha
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sousse, Fac Med Sousse, Lab Biophys Metab & Pharmacol Appliquee LR 12ES02, Sousse, TunisiaUniv Sousse, Fac Med Sousse, Lab Biophys Metab & Pharmacol Appliquee LR 12ES02, Sousse, Tunisia
Slim, Raoudha
Abdessayed, Nihed
论文数: 0引用数: 0
h-index: 0
机构:
Farhat Hached Hosp, Dept Anatomopathol, Sousse, TunisiaUniv Sousse, Fac Med Sousse, Lab Biophys Metab & Pharmacol Appliquee LR 12ES02, Sousse, Tunisia
Abdessayed, Nihed
Bensayed, Nesrine
论文数: 0引用数: 0
h-index: 0
机构:
Farhat Hached Hosp, Dept Clin Hematol, Sousse, TunisiaUniv Sousse, Fac Med Sousse, Lab Biophys Metab & Pharmacol Appliquee LR 12ES02, Sousse, Tunisia
Bensayed, Nesrine
Barka, Malek
论文数: 0引用数: 0
h-index: 0
机构:
Farhat Hached Univ Hosp Sousse, Dept Surg, Sousse, TunisiaUniv Sousse, Fac Med Sousse, Lab Biophys Metab & Pharmacol Appliquee LR 12ES02, Sousse, Tunisia
Barka, Malek
Fathallah, Neila
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sousse, Fac Med Sousse, Lab Biophys Metab & Pharmacol Appliquee LR 12ES02, Sousse, TunisiaUniv Sousse, Fac Med Sousse, Lab Biophys Metab & Pharmacol Appliquee LR 12ES02, Sousse, Tunisia
机构:
Xi An Jiao Tong Univ, Dept Gastroenterol, Affiliated Hosp 1, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Dept Gastroenterol, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China
Yang, Jiahui
Wu, Fangli
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Dept Gastroenterol, Affiliated Hosp 1, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Dept Gastroenterol, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China
Wu, Fangli
Luo, Dan
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Dept Geriatr, Affiliated Hosp 1, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Dept Gastroenterol, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China
Luo, Dan
Li, Miaojing
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Dept Hematol, Affiliated Hosp 1, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Dept Gastroenterol, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China
Li, Miaojing
Gou, Xinming
论文数: 0引用数: 0
h-index: 0
机构:
Shaanxi Prov Rehabil Hosp, Dept Neurosurg, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Dept Gastroenterol, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China
Gou, Xinming
Xi, Jieying
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Dept Hematol, Affiliated Hosp 1, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Dept Gastroenterol, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China
Xi, Jieying
Zhu, Huachao
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Dept Hematol, Affiliated Hosp 1, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Dept Gastroenterol, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China