Lack of association between matrix metalloproteinase-9 gene-1562C/T polymorphism and preeclampsia: a meta-analysis

被引：7

作者：

Gong, Li-Li ^{[1
]}

Liu, He ^{[1
]}

Liu, Li-Hong ^{[1
]}

机构：

[1] Beijing Capital Med Univ, Beijing Chao Yang Hosp, Beijing, Peoples R China

来源：

HYPERTENSION IN PREGNANCY | 2014年 / 33卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Matrix metalloproteinases; Meta analysis; Preeclampsia; Polymorphism; MATRIX METALLOPROTEINASES; HYPERTENSIVE DISORDERS; MMP-9; GENE;

D O I：

10.3109/10641955.2014.915033

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Studies investigating the association between matrix metalloproteinases (MMPs) gene polymorphisms and preeclampsia (PE) reported contradictory or non-conclusive results. We performed a meta-analysis of five studies that examined the relationship between PE and the MMP9-1562C>T polymorphism. The PubMed, Embase, and Google Scholar databases were searched to access the relevant genetic association studies up to September 2013. The meta-analysis revealed that there was no evidence for significant association between MMP9-1562C>T polymorphism and risk of PE. Large, multiethnic confirmatory, and well-designed studies are needed to further explore the relation between preeclampsia and polymorphisms of the MMPs gene.

引用

页码：389 / 394

页数：6

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