Nuclear Structures Regulate Liver-Specific Expression of the Tryptophan Oxygenase Gene

被引：0

作者：

Kaneoka, Hidenori ^{[1
]}

Miyake, Katsuhide ^{[1
]}

Iijima, Shinji ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Engn, Dept Biotechnol, Chikusa Ku, Nagoya, Aichi 4648603, Japan

来源：

ANIMAL CELL TECHNOLOGY: BASIC AND APPLIED ASPECTS, VOL 15 | 2009年 / 15卷

关键词：

Tryptophan oxygenase; glucocorticoid receptor; hepatocyte; ATTACHMENT REGIONS; MATRIX; SITES; TRANSCRIPTION; ELEMENTS; BINDING; LOOP; DNA; ORGANIZATION; HEPATOCYTES;

D O I：

10.1007/978-1-4020-9646-4_31

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The gene for tryptophan oxygenase (TO) is expressed in a tissue- and development-specific manner and is regulated by glucocorticoid hormone in rat liver. Transcription of the gene is induced 10-fold by glucocorticoids. The TO promoter has two glucocorticoid-responsive elements (GRE), located 450 bp and 1.2 kb Upstream from the cap site, and two TATA boxes. Combination of nuclear fractionation and quantitative PCR analysis showed that a putative matrix attachment region, which resides 8.5 kb upstream of the promoter, bound to nuclear matrix in the hormone-treated adult hepatocytes. However, this DNA region was partly released from the nuclear matrix by removing the hormone. These results indicated that binding of MAR to nuclear matrix was also important for regulation of the TO gene expression.

引用

页码：195 / 201

页数：7

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