A Look Inside of the Complex Pathogenesis of B-RAF(V600E)-Driven Cancer

被引：0
|
作者：
Caputo, Emilia [1 ]
机构：
[1] CNR, Inst Genet & Biophys IGB A Buzzati Traverso, Via Pietro Castellino 111, I-80131 Naples, Italy
来源：
THERANOSTICS | 2017年 / 7卷 / 07期
关键词：
D O I：
10.7150/thno.20460
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Cancer is a very complex disease, where cell alterations (i.e. gene mutations, dysregulated signaling pathway(s) and epigenetic modifications) contribute to its development and progression. Elucidating the connections among these cell modifications is a critical challenge, in order to understand the mechanisms which are activated from cancer cells to survive and proliferate. Interesting, Prof. Peng Hou and colleagues, at the First Affiliated Hospital of Xi'an Jiaotong University in China, identified unknown epigenetic mechanisms and their involvement in the tumorigenesis of B-RAF(V600E)-driven cancer.
引用
收藏
页码：2108 / 2110
页数：3
相关论文
共 50 条
  • [1] The inability of Spry2 to inhibit B-Raf V600E activity is required for induction of resistance to B-Raf inhibitor in B-Raf V600E cells
    Han, Byeal-I
    Ahn, Jun-Ho
    Jang, Gun-Hee
    Kim, Na-Yeon
    Lee, Michael
    FASEB JOURNAL, 2015, 29
  • [2] V600E B-Raf mutation is associated with chemoresistance in ovarian cancer
    Russo, Alessia E.
    Pellizzari, Ilenia
    Candido, Saverio
    Pezzino, Franca Maria
    Sorio, Roberto
    Baldassarre, Gustavo
    Canevari, Silvana
    McCubrey, James A.
    Libra, Massimo
    Scalisi, Aurora
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2013, 32 : S68 - S68
  • [3] The mechanism of activation of monomeric B-Raf V600E
    Maloney, Ryan C.
    Zhang, Mingzhen
    Jang, Hyunbum
    Nussinov, Ruth
    COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021, 19 : 3349 - 3363
  • [4] Activation mechanisms of clinically distinct B-Raf V600E and V600K mutants
    Zhang, Mingzhen
    Maloney, Ryan
    Liu, Yonglan
    Jang, Hyunbum
    Nussinov, Ruth
    CANCER COMMUNICATIONS, 2023, 43 (03) : 405 - 408
  • [5] Novel natural inhibitors targeting B-RAF(V600E) by computational study
    Wu, Bo
    Zhang, Zhiyun
    Dou, Gaojing
    Lv, Xiaye
    Ge, Junliang
    Wang, Hongyu
    Xie, Haoqun
    Zhu, Dong
    BIOENGINEERED, 2021, 12 (01) : 2970 - 2983
  • [6] Understanding the role of Raf signaling in B-Raf V600E mutant versus wildtype tumors
    Hatzivassiliou, G.
    Sideris, S.
    Yen, I.
    Gloor, S.
    Callejo, M.
    Brandhuber, B.
    Liu, B.
    Belvin, M.
    Malek, S.
    EJC SUPPLEMENTS, 2008, 6 (12): : 183 - 184
  • [7] Suppression of B-Raf(V600E) cancers by MAPK hyper-activation
    Atiq, Rawan
    Hertz, Rachel
    Eldad, Sophia
    Smeir, Elia
    Bar-Tana, Jacob
    ONCOTARGET, 2016, 7 (14) : 18694 - 18704
  • [8] Antitumor activity of PLX4032, a novel B-Raf V600E inhibitor
    Lee, J. T.
    Kong, J.
    Smalley, K.
    Tsai, J.
    Cho, H.
    Bollag, G.
    Herlyn, M.
    EJC SUPPLEMENTS, 2006, 4 (12): : 172 - 173
  • [9] Understanding the effects of RAF inhibitors on RAF signaling in B-RAF V600E mutant versus wild type tumors
    Yen, Ivana
    Song, Kyung
    Stokoe, David
    Brandhuber, Barbara
    Gloor, Susan
    Aliagas, Ignacio
    Anderson, Daniel
    Morales, Tony
    Vigers, Guy
    Ludlam, Mary
    Alvarado, Ryan
    Liu, Bonnie
    Sideris, Steve
    Ramaswamy, Sreema
    Heise, Christopher
    Belvin, Marcia
    Friedman, Lou
    Hatzivassiliou, Georgia
    Malek, Shiva
    MOLECULAR CANCER THERAPEUTICS, 2009, 8 (12)
  • [10] B-RAF INHIBITOR PLX4720 ENHANCES THE ACTIVITY OF RADIATION IN HUMAN MALIGNANT ASTROCYTOMAS EXPRESSING THE B-RAF V600E MUTATION
    Dasgupta, Tina
    Gragg, Ashley
    Prados, Michael
    Nicolaides, Theodore
    James, C. David
    Haas-Kogan, Daphne
    NEURO-ONCOLOGY, 2011, 13 : I35 - I36
12345