Discordant total and free prostate-specific antigen (PSA) assays: does calibration with WHO reference materials diminish the problem?

被引：26
|
作者：
Stephan, Carsten [1 ]
Koepke, Thomas [2 ]
Semjonow, Axel [2 ]
Lein, Michael [1 ,3 ]
Deger, Serdar [1 ]
Schrader, Mark [1 ]
Miller, Kurt [1 ]
Jung, Klaus [1 ,3 ]
机构：
[1] Charite Univ Med Berlin, Dept Urol, D-10117 Berlin, Germany
[2] Univ Clin Munster, Dept Urol, Prostate Ctr, Munster, Germany
[3] Berlin Inst Urol Res, Berlin, Germany
来源：
CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2009年 / 47卷 / 11期
关键词：
method comparison; prostate cancer; prostate-specific antigen; WHO PSA standards; 1ST INTERNATIONAL STANDARDS; MULTICENTER CLINICAL-TRIAL; ARTIFICIAL NEURAL-NETWORK; COMMERCIAL ASSAYS; CANCER-DETECTION; SERUM; BIOPSY; IMPACT; PERCENTAGE; BIAS;
D O I：
10.1515/CCLM.2009.285
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Prostate-specific antigen (PSA) assay-dependent variations could result in misinterpretation of individual PSA values. Therefore, the situation for clinical interpretation of PSA or percent free PSA (%fPSA) results is complicated. This review summarizes the differences in various total PSA (tPSA) and free PSA (fPSA) assays, and results obtained using the new World Health Organization (WHO) calibrated Access assays from various studies. Method comparisons between the traditionally calibrated Hybritech PSA and fPSA assays and the new "standardized" WHO calibrated assays yield results that are similar to 25% lower for PSA and fPSA. A PSA cut-off of 3 or 3.1 mu g/L should be considered for WHO calibrated assays in order to achieve the same sensitivity/specificity profile as with a cutoff of 4 mu g/L in traditionally calibrated assays. The %fPSA cut-offs could be retained. Clin Chem Lab Med 2009;47:1325-31.
引用
收藏
页码：1325 / 1331
页数：7
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