Meroterpenoids and alkaloids from Ganoderma australe

被引：26
|
作者：
Zhang, Jiao-Jiao [1 ,2 ]
Dong, Yun [1 ,3 ]
Qin, Fu-Ying [1 ,2 ]
Yan, Yong-Ming [1 ]
Cheng, Yong-Xian [1 ]
机构：
[1] Shenzhen Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, Shenzhen, Guangdong, Peoples R China
[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
[3] Chinese Acad Sci, Brain Cognit & Brain Dis Inst, Shenzhen Inst Adv Technol, Shenzhen, Guangdong, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 19期
基金：
中国国家自然科学基金;
关键词：
Ganoderma australe; meroterpenoids; alkaloids; neuroprotection; LUCIDUM; INHIBITORS; EXTRACT; POTENT;
D O I：
10.1080/14786419.2019.1693565
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two new mertoterpenoids, australins A (1) and B (2), and a new alkaloid, australine (4), together with five known compounds (3, 5-8) were isolated from the fruiting bodies of Ganoderma australe. Their structures including absolute configurations were assigned by using spectroscopic methods and electronic circular dichroism (ECD) calculations. Racemic australin A was further purified by chiral HPLC. Biological assessments reveal that compounds (+)-1 and 7 could significantly protect SH-SY5Y cells from glutamate-induced neural excitotoxicity.
引用
收藏
页码：3226 / 3232
页数：7
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