A new sterol sulfate, Sch 572423, from a marine sponge, Topsentia sp.

被引：35
|
作者：
Yang, SW
Buivich, A
Chan, TM
Smith, M
Lachowicz, J
Pomponi, SA
Wright, AE
Mierzwa, R
Patel, M
Gullo, V
Chu, M
机构：
[1] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA
[2] Harbor Branch Oceanog Inst Inc, Ft Pierce, FL 34946 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 10期
关键词：
D O I：
10.1016/S0960-894X(03)00260-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Bioassay-guided fractionation of an active fraction from a marine sponge Topsentia sp. in our marine fraction library (MFL) led to the isolation and identification of halistanol sulfate (1) and a new sterol sulfate Sch 572423 (2). Compounds 1 and 2 were identified as P2Y(12) inhibitors with IC50 Of 0.48 and 2.2 muM, respectively. The general method of purification for the MFL library and the structure elucidation of compound 2 are described. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1791 / 1794
页数：4
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