The Effect of Transplantation of Olfactory Ensheathing Cells on the Size of Posttraumatic Spinal Cord Cysts

被引：5

作者：

Voronova, A. D. ^{[1
]}

Stepanova, O. V. ^{[1
,5
]}

Chadin, A. V. ^{[1
]}

Fursa, G. A. ^{[1
,3
]}

Karsuntseva, E. K. ^{[1
,3
]}

Valikhov, M. P. ^{[1
,5
]}

Semkina, A. S. ^{[1
,2
]}

Reshetov, I. V. ^{[4
]}

Chekhonin, V. P. ^{[1
,2
]}

机构：

[1] Minist Hlth Russian Federat, VP Serbsky Natl Med Res Ctr Psychiat & Narcol, Moscow, Russia

[2] NI Pirogov Russian Natl Res Med Univ, Minist Hlth Russian Federat, Moscow, Russia

[3] Moscow MV Lomonosov State Univ, Moscow, Russia

[4] IM Sechenov First Moscow State Med Univ, Univ Clin Hosp 1, Minist Hlth Russian Federat, Moscow, Russia

[5] Minist Hlth Russian Federat, Natl Med Res Ctr Cardiol, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2021年 / 171卷 / 01期

关键词：

human olfactory mucosa; olfactory ensheathing cells; cell therapy; posttraumatic cysts of the spinal cord; NEURAL PRECURSOR CELLS; STEM-CELLS; RATS; RECOVERY; REGENERATION; INJURY;

D O I：

10.1007/s10517-021-05183-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effect of transplantation of ensheathing cells obtained from the olfactory mucosa of rats and humans on the size of posttraumatic spinal cord cysts. MRI examination showed that transplantation of these cells into experimental posttraumatic cysts of the spinal cord led to a significant decrease in cyst volume and even their complete disappearance in two animals receiving transplantation of rat or human cells. These findings attested to regenerative processes developing as a result of ensheathing cell transplantation. Further studies in this field will be aimed at elucidation of the mechanisms underlying spinal cord regeneration in the area of posttraumatic cysts after transplantation of ensheathing cells.

引用

页码：122 / 126

页数：5

共 50 条

[41] Influence of cryopreserved olfactory ensheathing cells transplantation on axonal regeneration in spinal cord of adult rats
沈慧勇
殷德振
唐勇
吴燕峰
程志安
杨睿
黄霖
中华创伤杂志(英文版), 2004, (03) : 52 - 56
[42] Functional Recovery Following the Transplantation of Olfactory Ensheathing Cells in Rat Spinal Cord Injury Model
Muniswami, Durai Murugan
Tharion, George
ASIAN SPINE JOURNAL, 2018, 12 (06) : 998 - 1009
[43] Influence of cryopreserved olfactory ensheathing cells transplantation on axonal regeneration in spinal cord of adult rats
沈慧勇
殷德振
唐勇
吴燕峰
程志安
杨睿
黄霖
Chinese Journal of Traumatology, 2004, (03)
[44] Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord
Lu, J
Féron, F
Mackay-Sim, A
Waite, PME
BRAIN, 2002, 125 : 14 - 21
[45] Olfactory ensheathing cells transplantation for Spinal cord Injury treatment: Still a long way to go
Yuan, Ti-Fei
MEDICAL HYPOTHESES, 2008, 71 (01) : 153 - 154
[46] Intravenous transplantation of olfactory bulb ensheathing cells for a spinal cord hemisection injury rat model
Zhang, Lijian
Zhuang, Xiaoqing
Chen, Yao
Xia, Hechun
CELL TRANSPLANTATION, 2019, 28 (12) : 1585 - 1602
[47] Transplantation of olfactory ensheathing cells or Schwann cells restores rapid and secure conduction across the transected spinal cord
Imaizumi, T
Lankford, KL
Kocsis, JD
BRAIN RESEARCH, 2000, 854 (1-2) : 70 - 78
[48] Gene Expression Changes in the Injured Spinal Cord Following Transplantation of Mesenchymal Stem Cells or Olfactory Ensheathing Cells
Torres-Espin, Abel
Hernandez, Joaquim
Navarro, Xavier
PLOS ONE, 2013, 8 (10):
[49] Acute transplantation of olfactory ensheathing cells or Schwann cells promotes recovery after spinal cord injury in the rat
García-Alías, G
López-Vales, R
Forés, J
Navarro, X
Verdú, E
JOURNAL OF NEUROSCIENCE RESEARCH, 2004, 75 (05) : 632 - 641
[50] Preparation of Human Olfactory Ensheathing Cells for the Therapy of Spinal Cord Injuries
А. D. Voronova
O. V. Stepanova
M. P. Valikhov
A. V. Chadin
А. S. Dvornikov
I. V. Reshetov
V. P. Chekhonin
Bulletin of Experimental Biology and Medicine, 2018, 164 : 523 - 527

← 1 2 3 4 5 →