The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

被引：21
|
作者：
Formicola, Beatrice [1 ]
Dal Magro, Roberta [1 ]
Montefusco-Pereira, Carlos, V [2 ]
Lehr, Claus-Michael [2 ]
Koch, Marcus [3 ]
Russo, Laura [4 ]
Grasso, Gianvito [5 ]
Deriu, Marco A. [6 ]
Danani, Andrea [5 ]
Bourdoulous, Sandrine [7 ]
Re, Francesca [1 ]
机构：
[1] Univ Milano Bicocca, Sch Med & Surg, Via Raoul Follereau 3, I-20854 Vedano Al Lambro, MB, Italy
[2] Saarland Univ, Helmholtz Inst Pharmaceut Res Saarland, Dept Drug Delivery, D-66123 Saarbrucken, Germany
[3] Leibniz Inst New Mat, Campus D22, D-66123 Saarbrucken, Germany
[4] Univ Milano Bicocca, Dept Biotechnol & Biosci, Bio Organ Chem Lab, Via Raoul Follereau 3, I-20854 Vedano Al Lambro, MB, Italy
[5] USI, SUPSI, IDSIA, Manno, Switzerland
[6] Politecn Torino, Dept Mech & Aerosp Engn DIMEAS, Corso Duca Abruzzi 24, I-10128 Turin, Italy
[7] INSERM, Inst Cochin, U1016, Paris, France
来源：
JOURNAL OF NANOBIOTECHNOLOGY | 2019年 / 17卷 / 01期
基金：
欧盟地平线“2020”;
关键词：
Nanoparticles; Liposomes; Brain; Blood-brain barrier; Drug delivery; Doxorubicin; Chlorotoxin; Glioblastoma; BLOOD-BRAIN-BARRIER; ALZHEIMERS-DISEASE; MEMORY IMPAIRMENT; ANNEXIN A2; PEPTIDE; TRANSPORT; THERAPY; MODEL;
D O I：
10.1186/s12951-019-0546-3
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.
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页数：7
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